Anti-SP-10 Antibody (Rabbit Polyclonal antibody) General Information
Reacts with: Human
Recombinant Human ACRV1 protein (Catalog#11789-H08H)
Produced in rabbits immunized with purified, recombinant Human ACRV1 (rh ACRV1; Catalog#11789-H08H, P26436-1, Gln 22-Ile 265). ACRV1 specific IgG was purified by Human ACRV1 affinity chromatography.
Polyclonal Rabbit IgG
Protein A & Antigen Affinity
0.2 μm filtered solution in PBS with 5% trehalose
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-SP-10 Antibody (Rabbit Polyclonal antibody) Validated Applications
**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********
Anti-SP-10 Antibody (Rabbit Polyclonal antibody) Images
Immunochemical staining of human ACRV1 in human testis with rabbit polyclonal antibody (1:20000, formalin-fixed paraffin embedded sections).
Anti-SP-10 Antibody Alternative Names
Anti-D11S4365 Antibody;Anti-SP-10 Antibody;Anti-SPACA2 Antibody
SP-10 Background Information
Acrosomal protein SP-10, also known as Acrosomal vesicle protein 1 and ACRV1, is a testis-specific, differentiation antigen, that arises within the acrosomal vesicle during spermatogenesis, and is associated with the acrosomal membranes and matrix of mature sperm. Regulation of cell type-specific gene transcription is central to cellular differentiation and development. During spermatogenesis, a number of testis-specific genes are expressed in a precise spatiotemporal order. The longest transcript of ACRV1 / SP-10 is the most abundant, comprising 53-72% of the total acrosomal vesicle protein 1 messages; the second largest transcript comprises 15-32%; the third and the fourth largest transcripts account for 3.4-8.3% and 8.7-12.5%, respectively; and the remaining transcripts combined account for < 1% of the total acrosomal vesicle protein 1 message. ACRV1 / SP-10 is a testis-specific acrosomal protein that has been detected in several species including humans. It may be involved in sperm-zona binding or penetration, and it is a potential contraceptive vaccine immunogen for humans. ACRV1 / SP-10 may be involved in sperm-zona binding or penetration. It is also a intra-acrosomal protein that is considered to be a vaccine candidate for immunocontraception.
acrosomal vesicle protein 1
Wright RM, et al.,1990, Biol Reprod. 42 (4): 693-701. Kurth,B.E. et al., 1993, Anat Rec. 236 (4):619-25. Golden WL, et al.,1994, Genomics.18 (2): 446-9. Foster,J.A. et al., 1994, Biol Reprod. 51 (6):1222-31. Abhyankar,M.M. et al., 2007, J Biol Chem. 282 (50): 36143-54.