ACP1 Protein (LMW-PTP Protein)

Acid Phosphatase 1 (Low molecular weight phosphotyrosine protein phosphatase)

ACP1 Products

ACP1 Protein, Recombinant

Molecule	Species	Description	Cat. No
ACP1/LMW-PTP	Human	ACP1/LMW-PTP Protein, Recombinant, with GST Tag	10957-H09E

ACP1 cDNA Clone

Molecule	Species	Description	Cat. No
ACP1/LMW-PTP	Human	Human ACP1/LMW-PTP cDNA Clone / ORF Clone	HG10957-M

ACP1 Related Areas

Enzyme>>Phosphatase & Regulator>>ACP1/LMW-PTP

Signal Transduction>>Phosphatase & Regulator>>ACP1/LMW-PTP

ACP1 Alternative Names

ACP1, HAAP, MGC111030, MGC3499, LMW-PTP, LMW-PTPase [Homo sapiens]

Acp1, 4632432E04Rik, AI427468, Acp-1, LMW-PTP, MGC103115, MGC132904, LMW-PTPase [Mus musculus]

ACP1 Background

The low molecular weight phosphotyrosine phosphatase (LMW-PTP), also known as Acid phosphatase 1 (ACP1), belongs to the low molecular weight phosphotyrosine protein phosphatase family are involved in the regulation of important physiological functions, including stress resistance and synthesis of the polysaccharide capsule. ACP1/LMW-PTP is an enzyme involved in platelet-derived growth factor-induced mitogenesis and cytoskeleton rearrangement. LMW-PTP is able to specifically bind and dephosphorylate activated PDGF receptor, thus modulating PDGF-induced mitogenesis. In vitro, LMW-PTP was found to efficiently dephosphorylate activated FcgammaRIIA and LAT, but not Syk or phospholipase Cgamma2. The overexpression of LMW-PTP inhibited activation of Syk downstream of FcgammaRIIA and reduced intracellular Ca(2+) mobilization. It been demonstrated that LMW-PTP is responsible for FcgammaRIIA dephosphorylation, and is implicated in the down-regulation of cell activation mediated by this ITAM-bearing immunoreceptor. In addition, ACP1 is a highly polymorphic phosphatase that is especially abundant in the central nervous system and is known to be involved in several signal transduction pathways.

ACP1 Related Studies

1. Cirri P, et al. (1998) Low molecular weight protein-tyrosine phosphatase tyrosine phosphorylation by c-Src during platelet-derived growth factor-induced mitogenesis correlates with its subcellular targeting. J Biol Chem. 273(49): 32522-7.
2. Chiarugi P, et al. (2002) Insight into the role of low molecular weight phosphotyrosine phosphatase (LMW-PTP) on platelet-derived growth factor receptor (PDGF-r) signaling. LMW-PTP controls PDGF-r kinase activity through TYR-857 dephosphorylation. J Biol Chem. 277(40): 37331-8.
3. Bottini N, et al. (2002) Convulsive disorder and the genetics of signal transduction; a study of a low molecular weight protein tyrosine phosphatase in a pediatric sample. Neurosci Lett. 333(3): 159-62.
4. Musumeci L, et al. (2005) Low-molecular-weight protein tyrosine phosphatases of Bacillus subtilis. J Bacteriol. 187(14): 4945-56.
5. Mancini F, et al. (2007) The low-molecular-weight phosphotyrosine phosphatase is a negative regulator of FcgammaRIIA-mediated cell activation. Blood. 110(6): 1871-8.