ACLY

ATP citrate lyase, also known as acly or acl, is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is composed of two polymer chains which are polypeptides in human. acly is responsible for catalyzing the conversion of citrate and CoA into acetyl-CoA and oxaloacetate, along with the hydrolysis of ATP. A definitive role for acly in tumorigenesis has emerged from acly RNAi and chemical inhibitor studies, showing that acly inhibition limits tumor cell proliferation and survival and induces differentiation in vitro. In vivo, it reduces tumor growth leading to a cytostatic effect and induces differentiation.

ACLY Related Areas

Cancer>>Apoptosis>>Inhibitor of Apoptosis (IAP)>>ACLY

ACLY Alternative Names

ACL, ATPCL, CLATP [Homo sapiens]

RP23-392I3.9, A730098H14Rik, AW538652 [Mus musculus]

Summaries for ACLY

Entrez Gene summary for ACLY:

Acly is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer (relative molecular weight approximately 440,000) of apparently identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and phosphate. The product, acetyl-CoA, serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis. In nervous tissue, Acly may be involved in the biosynthesis of acetylcholine. Two transcript variants encoding distinct isoforms have been identified for ACLY gene.

Wikipedia summary for ACLY:

Acly is an enzyme that represents an important step in fatty acid biosynthesis. This step in fatty acid biosynthesis occurs because Acly is the link between the metabolism of carbohydrates (which causes energy) and the production of fatty acids.

Human ACLY Protein General Information

 

• Protein names: ATP-citrate synthase, Short namen=ACLY
• Sequence length: 1101 AA.
• Domain: In the N-terminal section; Acly belongs to the succinate/malate CoA ligase beta subunit family. In the C-terminal section; Acly belongs to the succinate/malate CoA ligase alpha subunit family.
• Post-translational modification: ISGylated.
• Subunit structure: Homotetramer.
• Subcellular location: Cytoplasm.
• Catalytic activity: ADP + phosphate + acetyl-CoA + oxaloacetate = ATP + citrate + CoA.

General information above from UniProt

Function for ACLY Protein

UniProtKB:

Acly is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. It has a central role in de novo lipid synthesis. In nervous tissue Acly may be involved in the biosynthesis of acetylcholine.

Genatlas:

• Acly is used as a substrate for synthesis of the cytosolic acetyl-CoA
• Acly has a central role in lipid synthesis
• in nervous tissue Acly may be involved in the biosynthesis of acetylcholine