ACK1 / TNK2 Protein

Activated CDC42 Kinase 1/Tyrosine Kinase, non-receptor, 2

ACK1 / TNK2 Products

ACK1 / TNK2 Protein, Recombinant

Molecule	Species	Description	Cat. No
ACK1/TNK2	Human	ACK1/TNK2 Protein, Recombinant	11080-H09B

ACK1 / TNK2 cDNA Clone

Molecule	Species	Description	Cat. No
ACK1/TNK2	Human	Homo sapiens ACK1/TNK2 cDNA Clone	HG11080-M

ACK1 / TNK2 Related Areas

Enzyme>>Protein Kinase>>Intracellular Kinase>>ACK1/TNK2

Signal Transduction>>Protein Kinase>>Intracellular Kinase>>ACK1/TNK2

ACK1 / TNK2 Alternative Names

ACK1, TNK2, ACK, FLJ44758, FLJ45547, p21cdc42Hs [Homo sapiens]

ACK1, Tnk2, Ack, AW552477, Cdgip, MGC37479, Pyk1 [Mus musculus]

ACK1 / TNK2 Background

ACK1 (also known as ACK, TNK2, or activated Cdc42 kinase) is a structurally unique non-receptor tyrosine kinase that is expressed in diverse cell types. This downstream effector of CDC42 which mediates CDC42-dependent cell migration via phosphorylation of BCAR1. The ACK1 protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway. ACK1 integrates signals from plethora of ligand-activated receptor tyrosine kinases (RTKs), for example, MERTK, EGFR, HER2, PDGFR and insulin receptor to initiate intracellular signaling cascades. It binds to both poly- and mono-ubiquitin and regulates ligand-induced degradation of EGFR. ACK1 transduces extracellular signals to cytosolic and nuclear effectors such as the protein kinase AKT/PKB and androgen receptor (AR), to promote cell survival and growth. ACK1 participates in tumorigenesis, cell survival, and migration. Gene amplification and overexpression of ACK1 were found in many cancer types such as those of the lung and prostate. Recently, four somatic missense mutations of ACK1, which occur in the N-terminal region, the C-lobe of the kinase domain, and the SH3 domain, were identified in cancer tissue samples.

ACK1 / TNK2 Related Studies

1. Mahajan K, et al. (2010) Shepherding AKT and androgen receptor by Ack1 tyrosine kinase. J Cell Physiol. 224(2): 327-33.
2. Chua BT, et al. (2010) Somatic mutation in the ACK1 ubiquitin association domain enhances oncogenic signaling through EGFR regulation in renal cancer derived cells. Mol Oncol. 4(4): 323-34.
3. Prieto-Echagüe V, et al. (2010) Cancer-associated mutations activate the nonreceptor tyrosine kinase Ack1. J Biol Chem. 285(14): 10605-15.