ACE2 Protein & Antibody

Angiotensin-Converting Enzyme 2

ACE2 Products

ACE2 Protein, Recombinant

Molecule	Species	Description	Cat. No
ACE2	Human	ACE2/Fc Protein, Recombinant	10108-H02H
ACE2	Mouse	ACE2/Fc Protein, Recombinant	50249-M03H
ACE2	Mouse	ACE2 Protein, Recombinant	50249-M08H
ACE2	Rat	ACE2 Protein, Recombinant	80031-R08H

  50249-M03H: The specific activity is > 100 pmoles/min/µg. Measured by its ability to cleave a fluorogenic peptide substrate, Mca-YVADAPK(Dnp)-OH, (R&D Systems Catalog # ES007).

  50249-M08H: The specific activity is > 200 pmoles/min/µg. Measured by its ability to cleave a fluorogenic peptide substrate, Mca-YVADAPK(Dnp)-OH, (R&D Systems Catalog # ES007).

  80031-R08H: The specific activity is  >  300 pmol / min / µg. Measured by its ability to cleave a fluorogenic peptide substrate, Mca-YVADAPK(Dnp)-OH, ( R&D Systems, Catalog # ES007 ).

ACE2 Antibody

Molecule	Application	Description	Cat. No
Rat ACE2	WB, ELISA	ACE2 Antibody	80031-RP01
Rat ACE2	WB, ELISA	ACE2 Antibody (Antigen Affinity Purified)	80031-RP02

ACE2 cDNA Clone

Molecule	Species	Description	Cat. No
ACE2	Human	Homo sapiens ACE2 cDNA Clone(NM_021804.1)	HG10108-M
ACE2	Mouse	Mus musculus ACE2 cDNA Clone	MG50249-M
ACE2	Rat	Rattus norvegicus ACE2 cDNA Clone	RG80031-M

ACE2 Related Areas

Cardiovascular>>Blood Pressure Regulation>>ACE2

Enzyme>>Protease & Regulator>>Metalloprotease & Regulator>>ACE2

ACE2 Alternative Names

ACE2, ACEH, DKFZp434A014 [Homo sapiens]

Ace2, RP23-330O24.1, 2010305L05Rik [Mus musculus]

ACE2 Background

Angiotensin-converting enzyme 2 (ACE2), a first homolog of ACE, regulates the renin angiotensin system (RAS) by counterbalancing ACE activity. Accumulating evidence in recent years has demonstrated a physiological and pathological role of ACE2 in the cardiovascular, renal and respiratory systems. ACE2 also has an important role in blood pressure control. This enzyme, an homolog of ACE, hydrolyzes angiotensin (Ang) I to produce Ang-(1-9), which is subsequently converted into Ang-(1-7) by a neutral endopeptidase and ACE. ACE2 releases Ang-(1-7) more efficiently than its catalysis of Ang-(1-9) by cleavage of Pro(7)-Phe(8) bound in Ang II. Thus, the major biologically active product of ACE2 is Ang-(1-7), which is considered to be a beneficial peptide of the RAS cascade in the cardiovascular system. A physiological role for ACE2 has been implicated in hypertension, cardiac function, heart function and diabetes, and as a receptor of the severe acute respiratory syndrome coronavirus. In the acute respiratory distress syndrome (ARDS), ACE, AngII, and AT1R promote the disease pathogenesis, whereas ACE2 and the AT2R protect from ARDS. Importantly, ACE2 has been identified as a key SARS-coronavirus receptor and plays a protective role in severe acute respiratory syndrome (SARS) pathogenesis. Furthermore, the recent explosion of research into the ACE2 homolog, collectrin, has revealed a new physiological function of ACE2 as an amino acid transporter, which explains the pathogenic role of gene mutations in Hartnup disorder. This review summarizes and discusses the recently unveiled roles for ACE2 in disease pathogenesis.

ACE2 Related Studies

1. Koitka A, et al. (2008) Angiotensin converting enzyme 2 in the kidney. Clin Exp Pharmacol Physiol. 35(4): 420-5.
2. Raizada MK, et al. (2007) ACE2: a new target for cardiovascular disease therapeutics. J Cardiovasc Pharmacol. 50(2): 112-9.
3. Imai Y, et al. (2007) Angiotensin-converting enzyme 2 (ACE2) in disease pathogenesis. Circ J. 74(3): 405-10.
4. Turner AJ, et al. (2004) ACE2: from vasopeptidase to SARS virus receptor. Trends Pharmacol Sci. 25(6): 291-4.