ACBD6 Protein & Antibody

Acyl-CoA Binding Domain Containing 6

ACBD6 Products

ACBD6 Protein, Recombinant

Molecule	Species	Description	Cat. No
ACBD6	Human	ACBD6 Protein, Recombinant	11112-H07B

ACBD6 Antibody

Molecule	Application	Description	Cat. No
Human ACBD6	WB, ELISA	Rabbit Polyclonal Antibody	11112-RP01
Human ACBD6	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)	11112-RP02

ACBD6 cDNA Clone

Molecule	Species	Description	Cat. No
ACBD6	Human	Homo sapiens ACBD6 cDNA Clone	HG11112-M

ACBD6 Alternative Names

ACBD6, MGC2404 [Homo sapiens]

Acbd6, 0610010G04Rik, 2610100E10Rik, MGC106946, MGC144461, MGC144462 [Mus musculus]

ACBD6 Background

Human acyl-coenzyme A binding domain-containing member 6 (ACBD6) is a modular protein that carries an acyl-CoA binding domain at its N terminus and two ankyrin motifs at its C terminus. In mammals, there are six members of the acyl-CoA binding domain-containing (ACBD) family, and their annotation is not uniform. All six ACBD proteins contain an ACB domain at the N terminus, but they do not share significant homology at the C-terminal region. ACBD6 is a 32 kDa protein that is predicted by sequence analysis to carry an ACB domain between residues 42 and 125 and two ANK motifs at its C terminus. This protein binds long-chain acyl-CoAs with a strong preference for unsaturated, C18:1-CoA and C20:4-CoA, over saturated, C16:0-CoA, acyl species. ACBD6 is not a ubiquitous protein, but it is expressed in hematopoietic tissues and appears to be restricted to primitive stem cells present in those tissues with functions in blood and vessel development. ACBD6 was detected in bone marrow, spleen, placenta, cord blood, circulating CD34+ progenitors, and embryonic-like stem cells derived from placenta. In placenta, the protein was only detected in CD34+ progenitor cells present in blood and in CD31+ endothelial cells surrounding the blood vessels. These cells were also positive for the marker CD133, and they probably constitute hemangiogenic stem cells, precursors of both blood and vessels. We propose that human ACBD6 represents a cellular marker for primitive progenitor cells with functions in hematopoiesis and vascular endothelium development.

ACBD6 Related Studies

1. Soupene E, et al. (2008) Characterization of an acyl-coenzyme A binding protein predominantly expressed in human primitive progenitor cells. J Lipid Res. 49(5): 1103-12.