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ABI2  Protein

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ABI2 Related Area

ABI2 Related Pathways

    ABI2 Related Protein, Antibody, cDNA Gene, and ELISA Kits

    ABI2 Related Protein, Antibody, cDNA Gene, and ELISA Kits

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    ABI2 Summary & Protein Information

    ABI2 Background

    Subunit structure: Component of the WAVE1 complex composed of ABI2, CYFIP1 or CYFIP2, BRK1, NCKAP1 and WASF1/WAVE1. Within the complex, a heterdimer containing NCKAP1 and CYFIP1 interacts with a heterotrimer formed by WAVE1, ABI2 and BRK1. CYFIP2 binds to activated RAC1 which causes the complex to dissociate, releasing activated WASF1. The complex can also be activated by NCK1 (By similarity). Interacts with ABL1 and ABL2. {ECO:0000250, ECO:0000269|PubMed:21107423, ECO:0000269|PubMed:7590236, ECO:0000269|PubMed:8649853}.
    Subcellular location: Cytoplasm {ECO:0000250}.; Isoform 1: Cell projection, lamellipodium {ECO:0000250}. Cell projection, filopodium {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Isoform 1 but not isoform 3 is localized to protruding lamellipodia and filopodia tips. {ECO:0000250}.
    Post-translational: Is a substrate for ABL1.
    Sequence similarity: Belongs to the ABI family. {ECO:0000305}.; Contains 1 SH3 domain. {ECO:0000255|PROSITE-ProRule:PRU00192}.; Contains 1 t-SNARE coiled-coil homology domain. {ECO:0000255|PROSITE-ProRule:PRU00202}.
    General information above from UniProt

    ABI2 Alternative Name

    ABI-2,ABI2B,AIP-1,AblBP3,argBP1,SSH3BP2,argBPIA,argBPIB, [homo-sapiens]
    AI839867,C130078H13,8430425M24Rik, [mus-musculus]

    ABI2 Related Studies

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