+86-400-890-9989
Product Catalog
> ABHD4 ABHD4
Abhydrolase domain containing 4 (ABHD4), also known as alpha/beta-hydrolase 4 (ABH4), or lyso-N-acylphosphatidylethanolamine lipase, which belongs to the ABHD4/ABHD5 subfamily of peptidase S33 family. Abhydrolase domain containing (ABHD) gene was a small group belongs to alpha/beta hydrolase superfamily. Known members of this group are all found to be involved in important biochemical processes and related to various diseases. The alpha/beta-hydrolase 4 (ABH4) is a lysophospholipase/phospholipase B that selectively hydrolyzes N-acyl phosphatidylethanolamines (NAPEs) and lysoNAPEs. ABHD4 accepts lysoNAPEs bearing both saturated and polyunsaturated N-acyl chains as substrates and displays a distribution that closely mirrors lysoNAPE-lipase activity in mouse tissues. The existence of an NAPE-PLD-independent route for NAE biosynthesis and suggest that ABHD4 plays a role in this metabolic pathway by acting as a (lyso)NAPE-selective lipase.
- Research Tools:
Protein, cDNA Clone,
Antibody, ELISA Kit - All Produced in House
- Quality Guarantee
- Bulk Order
- Cost Saving
- Products (protein, antibody, ELISA kit, cDNA clone)
- Related Areas (research topics)
- Pathways
- Alternative Names
- Summaries
- Protein General Information
(domain, location, disease, etc) - Function
- Homology
- Phenotype (disorder & disease)
- Drugs
- Hot Molecules
ABHD4 Related Products
ABHD4 Proteins
ABHD4 Antibodies
- Anti-Human ABHD4 Antibody, Rabbit PAb, Cat NO: 11097-RP01
- Anti-Human ABHD4 Antibody, Rabbit PAb (Antigen Affinity Purified), Cat NO: 11097-RP02
ABHD4 ELISA Pair sets
ABHD4 cDNA Clones
- Homo sapiens ABHD4 cDNA Clone, Cat NO: HG11097-M
- Mouse ABHD4 cDNA Clone / ORF Clone, Cat NO: MG50747-G
ABHD4 Related Areas
Enzyme>>Lipid Metabolism Enzymes>>ABHD4
Cardiovascular>>Lipid Metabolism>>Lipid Metabolism Enzymes>>ABHD4
ABHD4 Related Pathways
ABHD4 Alternative Names
ABHD4, ABH4, FLJ12816 [Homo sapiens]
ABHD4, Abh4, 1110035H23Rik, AI429574 [Mus musculus]
Summaries for ABHD4
Human ABHD4 Protein General Information
| Protein names |
Abhydrolase domain-containing protein 4 |
| Sequence length |
342 AA. |
| Sequence similarities: |
ABHD4 belongs to the peptidase S33 family. ABHD4/ABHD5 subfamily. |
| Caution: |
Thr-291 is present instead of the conserved His which is expected to be an active site residue. |
General information above from UniProt
Function for ABHD4 Protein
UniProtKB:
ABHD4 is lysophospholipase selective for N-acyl phosphatidylethanolamine (NAPE). ABHD4 contributes to the biosynthesis of N-acyl ethanolamines, including the endocannabinoid anandamide by hydrolyzing the sn-1 and sn-2 acyl chains from N-acyl phosphatidylethanolamine (NAPE) generating glycerophospho-N-acyl ethanolamine (GP-NAE), an intermediate for N-acyl ethanolamine biosynthesis. ABHD4 hydrolyzes substrates bearing saturated, monounsaturated, polyunsaturated N-acyl chains. ABHD4 shows no significant activity towards other lysophospholipids, including lysophosphatidylcholine, lysophosphatidylethanolamine and lysophosphatidylserine
