ABHD4 Protein & Antibody

Abhydrolase domain containing 4

ABHD4 Products

ABHD4 Protein, Recombinant

Molecule	Species	Description	Cat. No
ABHD4	Human	ABHD4 Protein, Recombinant	11097-H07B

ABHD4 Antibody

Molecule	Application	Description	Cat. No
Human ABHD4	WB, ELISA	ABHD4 Antibody, Rabbit PAb	11097-RP01
Human ABHD4	WB, ELISA	ABHD4 Antibody, Rabbit PAb (Antigen Affinity Purified)	11097-RP02

ABHD4 cDNA Clone

Molecule	Species	Description	Cat. No
ABHD4	Human	Homo sapiens ABHD4 cDNA Clone	HG11097-M
ABHD4	Human	Mouse ABHD4 cDNA Clone / ORF Clone	MG50747-G

ABHD4 Related Areas

Enzyme>>Lipid Metabolism Enzymes>>ABHD4

Cardiovascular>>Lipid Metabolism>>Lipid Metabolism Enzymes>>ABHD4

ABHD4 Alternative Names

ABHD4, ABH4, FLJ12816 [Homo sapiens]

ABHD4, Abh4, 1110035H23Rik, AI429574 [Mus musculus]

ABHD4 Background

Abhydrolase domain containing 4 (ABHD4), also known as alpha/beta-hydrolase 4 (ABH4) , or lyso-N-acylphosphatidylethanolamine lipase, which belongs to the ABHD4/ABHD5 subfamily of peptidase S33 family. Abhydrolase domain containing (ABHD) gene was a small group belongs to alpha/beta hydrolase superfamily. Known members of this group are all found to be involved in important biochemical processes and related to various diseases. The alpha/beta-hydrolase 4 (ABH4) is a lysophospholipase/phospholipase B that selectively hydrolyzes N-acyl phosphatidylethanolamines (NAPEs) and lysoNAPEs. ABH4 accepts lysoNAPEs bearing both saturated and polyunsaturated N-acyl chains as substrates and displays a distribution that closely mirrors lysoNAPE-lipase activity in mouse tissues. The existence of an NAPE-PLD-independent route for NAE biosynthesis and suggest that ABH4 plays a role in this metabolic pathway by acting as a (lyso)NAPE-selective lipase.

ABHD4 Related Studies

1. Li F, et al. (2009) An unannotated alpha/beta hydrolase superfamily member, ABHD6 differentially expressed among cancer cell lines. Mol Biol Rep. 36(4): 691-6.
2. Simon G.M, et al. (2006) Endocannabinoid biosynthesis proceeding through glycerophospho-N-acyl ethanolamine and a role for alpha/beta hydrolase 4 in this pathway. J. Biol. Chem. 281: 26465-72.