BCRP / ABCG2: BCRP / ABCG2 Protein | BCRP / ABCG2 Antibody

BCRP / ABCG2 Gene family

BCRP / ABCG2 Background

ATP-binding cassette subfamily G member 2 (ABCG2), a member of the ABC transporter superfamily proteins. the expression of ABCG2 is related to tumorigenic cancer stem cells (CSC) in several cancers, mediates multidrug resistance (MDR) by transporting substrate anticancer drugs out of cancer cells and decreasing their intracellular accumulation. ABCB1 and ABCG2 are efflux transporters which have a major impact on the pharmacological behavior of numerous drugs. They are expressed in the intestine, liver, kidney, BBB and placenta. It has become evident that ABCB1 and ABCG2 modify the pharmaco/toxicokinetics in the placenta and fetus and may consequently affect the outcome of pregnancy.

Reference for BCRP / ABCG2

  • Guo X, et al. (2018) Dacomitinib potentiates the efficacy of conventional chemotherapeutic agents via inhibiting the drug efflux function of abcg2 in vitro and in vivo. J Exp Clin Cancer Res 37(1), 31.
  • Sasaki N, et al. (2018) Stemness and anti-cancer drug resistance in atp-binding cassette subfamily g member 2 highly expressed pancreatic cancer is induced in 3d culture conditions. Cancer Sci 109(4), 1135-1146.
  • Myllynen P, et al. (2010) Abcb1 and abcg2 expression in the placenta and fetus: An interspecies comparison. Expert Opin Drug Metab Toxicol 6(11), 1385-1398.

BCRP / ABCG2 Protein

BCRP / ABCG2 protein function

High-capacity urate exporter functioning in both renal and extrarenal urate excretion. Plays a role in porphyrin homeostasis as it is able to mediates the export of protoporhyrin IX (PPIX) both from mitochondria to cytosol and from cytosol to extracellular space, and cellular export of hemin, and heme. Xenobiotic transporter that may play an important role in the exclusion of xenobiotics from the brain. Appears to play a major role in the multidrug resistance phenotype of several cancer cell lines. Implicated in the efflux of numerous drugs and xenobiotics: mitoxantrone, the photosensitizer pheophorbide, camptothecin, methotrexate, azidothymidine (AZT), and the anthracyclines daunorubicin and doxorubicin. {ECO:0000269|PubMed:12958161, ECO:0000269|PubMed:20705604, ECO:0000269|PubMed:22132962, ECO:0000269|PubMed:23189181}.

BCRP / ABCG2 protein expression

Tissue specificity

Highly expressed in placenta. Low expression in small intestine, liver and colon.

Induction

Up-regulated in brain tumors.

BCRP / ABCG2 protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    655.00
  • Mass (Da)
    72.00

BCRP / ABCG2 Antibody

There are 3 BCRP / ABCG2 antibodies which are validated in multiple tissues with various applications, including WB, IP, IHC-P. There are 2 BCRP / ABCG2 antibody for WB, 1 BCRP / ABCG2 antibody for IP, 1 BCRP / ABCG2 antibody for IHC-P. Among all these BCRP / ABCG2 antibodies, there are 3 anti-BCRP / ABCG2 rabbit polyclonal antibodies . All the BCRP / ABCG2 anbodies are produced in house and all are in stock. BCRP / ABCG2 antibody customerized service is available.

BCRP / ABCG2 Gene

The protein encoded by this gene is a protease inhibitor and cytokine transporter. It uses a bait-and-trap mechanism to inhibit a broad spectrum of proteases, including trypsin, thrombin and collagenase. It can also inhibit inflammatory cytokines, and it thus disrupts inflammatory cascades. Mutations in this gene are a cause of alpha-2-macroglobulin deficiency. This gene is implicated in Alzheimer's disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. A related pseudogene, which is also located on the p arm of chromosome 12, has been identified. [NCBI]