ABCB5: ABCB5 protein | ABCB5 antibody

ABCB5 General information

ABCB5 Reagents


ABCB5 Reagents • Anti-ABCB5 antibody
APPROVED SYMBOL
 ABCB5
APPROVED NAME
 ATP binding cassette subfamily B member 5
HGNC ID
 HGNC:46
SYNONYMS
 ABCB5alpha, ABCB5beta, ATP-binding cassette protein, EST422562, P-glycoprotein ABCB5
LOCUS TYPE
 gene with protein product
CHROMOSOMAL LOCATION
 7p21.1
HCOP
Orthology Predictions for ABCB5 From HGNC

From HGNC

ABCB5 Gene family protein & antibody (ATP binding cassette subfamily B)

Approved Symbol
Common name
Reagent list
ABCB1
ABCB1
ABCB11
ABCB11
ABCB6
ABCB6
ABCB8
ABCB8
TAP1
TAP1
Approved Symbol
Common name
Reagent list
ABCB10
ABCB10
ABCB4
ABCB4
ABCB7
ABCB7
ABCB9
ABCB9
TAP2
TAP2

ABCB5 Gene family members (ATP binding cassette subfamily B)

Approved Symbol
Approved Name
Synonyms
ABCB1
ABC20, CD243, GP170, multidrug resistance protein 1, P-gp
ABCB10
ABC transporter 10 protein, ATP-binding cassette sub-family B member 10, mitochondrial, ATP-binding cassette transporter 10, EST20237, M-ABC2, mitochondrial ATP-binding cassette 2, MTABC2
ABCB11
ABC member 16, MDR/TAP subfamily, ABC16, PFIC-2, PGY4, SPGP
ABCB4
GBD1, MDR2, PFIC-3
ABCB6
ATP-binding cassette half-transporter, EST45597, MTABC3, umat
ABCB7
ASAT, Atm1p, EST140535
ABCB8
EST328128, MABC1, M-ABC1, mitochondrial ABC protein
ABCB9
EST122234
TAP1
D6S114E, PSF1, RING4
TAP2
D6S217E, PSF2, RING11

ABCB5 Protein

ABCB5 protein function

Drug efflux transporter present in a number of stem cells that acts as a regulator of cellular differentiation. Able to mediate efflux from cells of the rhodamine dye and of the therapeutic drug doxorubicin. Specifically present in limbal stem cells, where it plays a key role in corneal development and repair. {ECO:0000269|PubMed:12960149, ECO:0000269|PubMed:15205344, ECO:0000269|PubMed:15899824, ECO:0000269|PubMed:22306008}.

ABCB5 protein expression

Tissue specificity

Expressed by CD133-expressing progenitor cells among epidermal melanocytes (at protein level). Widely expressed with specific expression in pigment cells. Highly expressed in several malignant tissues: highly expressed in clinical melanomas, with low expression in normal skin. In melanoma, marks malignant melanoma-initiating cells (MMIC), in which clinical virulence resides as a consequence of unlimited self-renewal capacity, resulting in inexorable tumor progression and metastasis. Also highly expressed in a number of leukemia cells. Expressed in basal limbal epithelium.


ABCB5 protein sequence

Length: 1,257.00

Mass (Da): 138.00

This sequence information is just for reference only.From Uniport

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ABCB5 Gene

The protein encoded by this gene is a protease inhibitor and cytokine transporter. It uses a bait-and-trap mechanism to inhibit a broad spectrum of proteases, including trypsin, thrombin and collagenase. It can also inhibit inflammatory cytokines, and it thus disrupts inflammatory cascades. Mutations in this gene are a cause of alpha-2-macroglobulin deficiency. This gene is implicated in Alzheimer's disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. A related pseudogene, which is also located on the p arm of chromosome 12, has been identified. [NCBI]

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