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MDR1/ABCB1  Protein

All ABCB1 Reagents

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MDR1/ABCB1 Related Pathways

    MDR1/ABCB1 Summary & Protein Information

    MDR1/ABCB1 Background

    Catalytic activity: ATP + H(2)O + xenobiotic(In) = ADP + phosphate + xenobiotic(Out).
    Subunit structure: Interacts with PSMB5.
    Subcellular location: Cell membrane; Multi-pass membrane protein (By similarity).
    Tissue specificity: Expressed in liver, kidney, small intestine and brain.
    Involvement in disease: Inflammatory bowel disease 13 (IBD13) [MIM:612244]: A chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
    Sequence similarity: Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.
    Contains 2 ABC transmembrane type-1 domains.
    Contains 2 ABC transporter domains.
    General information above from UniProt

    MDR1/ABCB1 Alternative Name

    MDR1/ABCB1 Related Studies

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"