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ABCB1  ELISA Pair Set

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ABCB1 ELISA Pair Set

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    ABCB1 Related Protein, Antibody, cDNA Gene, and ELISA Kits

    ABCB1 Related Protein, Antibody, cDNA Gene, and ELISA Kits

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    ABCB1 Summary & Protein Information

    ABCB1 Background

    Catalytic activity: ATP + H(2)O + xenobiotic(In) = ADP + phosphate + xenobiotic(Out).
    Subunit structure: Interacts with PSMB5. Finds in a complex with ABCB1, TFPI2 and PPP2R3C; leading to the dephosphorylation of ABCB1. {ECO:0000269|PubMed:15488952, ECO:0000269|PubMed:24333728}.
    Subcellular location: Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00441}.
    Tissue specificity: Expressed in liver, kidney, small intestine and brain.
    Involvement in disease: DISEASE: Inflammatory bowel disease 13 (IBD13) [MIM:612244]: A chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
    Sequence similarity: Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily. {ECO:0000305}.; Contains 2 ABC transmembrane type-1 domains. {ECO:0000255|PROSITE-ProRule:PRU00441}.; Contains 2 ABC transporter domains. {ECO:0000255|PROSITE-ProRule:PRU00434}.
    General information above from UniProt

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