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GABA-transaminase/ABAT  Protein

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GABA-transaminase/ABAT Related Pathways

GABA-transaminase/ABAT Related Protein, Antibody, cDNA Gene, and ELISA Kits

GABA-transaminase/ABAT Related Protein, Antibody, cDNA Gene, and ELISA Kits

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GABA-transaminase/ABAT Summary & Protein Information

GABA-transaminase/ABAT Background

Catalytic activity: 4-aminobutanoate + 2-oxoglutarate = succinate semialdehyde + L-glutamate.
(S)-3-amino-2-methylpropanoate + 2- oxoglutarate = 2-methyl-3-oxopropanoate + L-glutamate.
Cofactor: Pyridoxal phosphate.
Subunit structure: Homodimer; disulfide-linked.
Subcellular location: Mitochondrion matrix.
Tissue specificity: Liver > pancreas > brain > kidney > heart > placenta.
Involvement in disease: GABA transaminase deficiency (GABATD) [MIM:613163]: An enzymatic deficiency resulting in psychomotor retardation, hypotonia, hyperreflexia, lethargy, refractory seizures, and EEG abnormalities. Note=The disease is caused by mutations affecting the gene represented in this entry.
Sequence similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
General information above from UniProt

GABA-transaminase/ABAT Alternative Name

GABAT,NPD009,GABA-AT, [homo-sapiens]
I54,Gabat,Gabaat,Gm9851,Laibat,X61497,AI255750,9630038C02Rik,ENSMUSG00000051226, [mus-musculus]

GABA-transaminase/ABAT Related Studies

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