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AARSD1  Gene / cDNA Clone

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HP102930 
MP202581 

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AARSD1 Related Area

AARSD1 Related Pathways

    AARSD1 Summary & Protein Information

    AARSD1 Background

    Cofactor: Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000305}; ; Note=Binds 1 zinc ion per subunit. {ECO:0000305};
    Subcellular location: Cytoplasm {ECO:0000250}.
    Sequence similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily. {ECO:0000305}.
    General information above from UniProt

    AARSD1 belongs to the class-II aminoacyl-tRNA synthetase family, Alax-L subfamily. AARSD1 binds 1 zinc ion per subunit functions in trans to edit the amino acid moiety from incorrectly charged tRNA(Ala). Four transcript variants have been described for AARSD1: NM_025267.3, NM_001136042.2, NM_001142653.1 and NM_001142654.1. It has been determined that the latter two variants represent a distinct upstream locus, which is now represented by GeneID:100885848 (PTGES3L), while the former two variants represent readthrough transcripts between PTGES3L and this locus (AARSD1). The readthrough locus (PTGES3L-AARSD1) is now represented by GeneID:100885850.

    AARSD1 Alternative Name

    AARSD1 Related Studies

  • Tatham MH, et al. (2011) Comparative proteomic analysis identifies a role for SUMO in protein quality control. Oncogene. 19(17):2120-8.
  • Kim W, et al. (2011) Systematic and quantitative assessment of the ubiquitin-modified proteome. Mol Cell. 44(2):325-40.
  • Udeshi ND, et al. (2012) Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. Mol Cell Proteomics. 11(5):148-59.
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