AAMP: AAMP Protein | AAMP Antibody

AAMP Gene family

AAMP Protein

AAMP protein function

Plays a role in angiogenesis and cell migration. In smooth muscle cell migration, may act through the RhoA pathway.

AAMP protein expression

Tissue specificity

Expressed in metastatic melanoma, liver, skin, kidney, heart, lung, lymph node, skeletal muscle and brain, and also in A2058 melanoma cells and activated T-cells (at protein level). Expressed in blood vessels. Strongly expressed in endothelial cells, cytotrophoblasts, and poorly differentiated. colon adenocarcinoma cells found in lymphatics.

AAMP protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    434.00
  • Mass (Da)
    46.00

AAMP Gene

The protein encoded by this gene is a protease inhibitor and cytokine transporter. It uses a bait-and-trap mechanism to inhibit a broad spectrum of proteases, including trypsin, thrombin and collagenase. It can also inhibit inflammatory cytokines, and it thus disrupts inflammatory cascades. Mutations in this gene are a cause of alpha-2-macroglobulin deficiency. This gene is implicated in Alzheimer's disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. A related pseudogene, which is also located on the p arm of chromosome 12, has been identified. [NCBI]