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AADAC/arylacetamide deacetylase  Gene / cDNA Clone

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HP100612 
MP200269 

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    AADAC/arylacetamide deacetylase Summary & Protein Information

    AADAC/arylacetamide deacetylase Background

    Catalytic activity: Triacylglycerol + H(2)O = diacylglycerol + a carboxylate.
    Subcellular location: Endoplasmic reticulum membrane; Single-pass type II membrane protein. Microsome membrane; Single-pass type II membrane protein.
    Tissue specificity: Detected in liver (at protein level). Mainly expressed in liver, small intestine, colon, adrenal gland and bladder. {ECO:0000269|PubMed:19339378, ECO:0000269|PubMed:22207054, ECO:0000269|PubMed:22415931}.
    Induction: Down-regulated following infection with hepatis C virus which results in impaired triacylglycerol lipolysis and impaired assembly of very low density lipoproteins. This may represent a cellular adaptation to infection that is aimed at limiting viral production. {ECO:0000269|PubMed:23542347}.
    Post-translational: Glycosylation is required for enzyme activity. {ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:24125761}.
    Sequence similarity: Belongs to the 'GDXG' lipolytic enzyme family. {ECO:0000305}.
    General information above from UniProt

    AADAC/arylacetamide deacetylase Alternative Name

    AADAC/arylacetamide deacetylase Related Studies

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