Sino Biological provides a comprehensive set of tools for the study of ADAM & ADAMTS, including recombinant proteins, antibodies (mouse mAbs, rabbit mAbs, and rabbit pAbs), ELISA kits, and ORF cDNA clones.
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The A Disintegrin And Metalloprotease (ADAM) and ADAMTS (ADAM with Thrombospondin Motifs) proteins belong to the metzincin-superfamily of Zn-dependent metalloproteinases that shed the extracellular domains of membrane-bound growth factors, cytokines and their receptors. For example, ADAM17 is the principal protease involved in the activation of pro-TNF-alpha, and it is also required for generation of the active forms of epidermal growth factor receptor (EGFR) ligands. Another major family member, ADAM10, can cut off part of the HER2 receptor, activating it. In addition, ADAM10 also plays a key role in signaling via the Notch and Eph/ephrin pathways. Growth factors, cytokines and their receptors play a central role in cell signaling, cleavage by ADAM sheddases is essential for their subsequent "regulated intramembrane proteolysis" (RIP), which generates cleaved intracellular domains that translocate to the nucleus and regulate gene transcription. The ADAM family are thus fundamental to many control processes in development (such as angiogenesis, cell proliferation, metastasis) and homeostasis. Emerging evidence has suggested that they are also linked to pathological states when their functions are dysregulated, including cancer, cardiovascular disease, Alzheimer's disease, asthma, and other diseases.