Quick Order

Related Family Members
Protein Wiki by Initials

4E-BP1/EIF4EBP1

4E-BP1/EIF4EBP1 Protein & Antibody

Entrez Gene Summary for 4E-BP1/EIF4EBP1


This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation.

OMIM-Description for 4E-BP1/EIF4EBP1


inhibited the mTORC1 (601231) pathway in cells lacking EIF4EBP1, EIF4EBP2 (602224), and EIF4EBP3 (603483) and analyzed the effects on cell size, cell proliferation, and cell cycle progression. Although the EIF4EBPs had no effect on cell size, they inhibited cell proliferation by selectively inhibiting the translation of mRNAs that encode proliferation-promoting proteins and proteins involved in cell cycle progression. Thus, Dowling et al. (2010) concluded that control of cell size and cell cycle progression appear to be independent in mammalian cells, whereas in lower eukaryotes, EIF4E binding proteins influence both cell growth and proliferation.

.zh=4E-BP1/EIF4EBP1


EIF4EBP1

4E-BP1/EIF4EBP1 Alternative Names

4E-BP1/EIF4EBP1 Related Products

4E-BP1/EIF4EBP1 Proteins

Product nameProduct name
Human 4E-BP1 / EIF4EBP1 Protein (His Tag)

4E-BP1/EIF4EBP1 Antibodies

Product nameProduct name
4E-BP1 / EIF4EBP1 Antibody, Rabbit MAb4E-BP1 / EIF4EBP1 Antibody, Mouse MAb4E-BP1 / EIF4EBP1 Antibody, Mouse MAb4E-BP1 / EIF4EBP1 Antibody, Rabbit MAb4E-BP1 / EIF4EBP1 Antibody (FITC), Mouse MAb4E-BP1 / EIF4EBP1 Antibody (PE), Mouse MAb4E-BP1 / EIF4EBP1 Antibody, Rabbit PAb4E-BP1 / EIF4EBP1 Antibody, Rabbit MAb4E-BP1 / EIF4EBP1 Antibody, Rabbit PAb, Antigen Affinity Purified

4E-BP1/EIF4EBP1 cDNA Clones

Product nameProduct name
Human 4E-BP1/EIF4EBP1 Gene ORF cDNA clone expression plasmid, N-GFPSpark tagHuman 4E-BP1/EIF4EBP1 Gene ORF cDNA clone expression plasmid, N-His tagMouse 4E-BP1/EIF4EBP1 Gene ORF cDNA clone expression plasmid, N-Myc tagMouse 4E-BP1/EIF4EBP1 Gene ORF cDNA clone expression plasmid, N-His tagHuman 4E-BP1/EIF4EBP1 Gene ORF cDNA clone expression plasmid, C-GFPSpark tagHuman 4E-BP1/EIF4EBP1 Gene ORF cDNA clone expression plasmid, C-Myc tagHuman 4E-BP1/EIF4EBP1 Gene ORF cDNA clone expression plasmid, N-Flag tagMouse 4E-BP1/EIF4EBP1 Gene ORF cDNA clone expression plasmid, C-OFPSpark tagMouse 4E-BP1/EIF4EBP1 Gene ORF cDNA clone expression plasmid, N-OFPSpark tagMouse 4E-BP1/EIF4EBP1 Gene ORF cDNA clone expression plasmid, N-GFPSpark tagHuman 4E-BP1/EIF4EBP1 Gene ORF cDNA clone expression plasmid, N-HA tagHuman 4E-BP1/EIF4EBP1 Gene ORF cDNA clone in cloning vectorHuman 4E-BP1/EIF4EBP1 Gene ORF cDNA clone expression plasmid, C-HA tagHuman 4E-BP1/EIF4EBP1 Gene ORF cDNA clone expression plasmid, C-OFPSpark tagHuman 4E-BP1/EIF4EBP1 Gene ORF cDNA clone expression plasmid, N-OFPSpark tagMouse 4E-BP1/EIF4EBP1 Gene ORF cDNA clone expression plasmid, N-HA tagMouse 4E-BP1/EIF4EBP1 Gene ORF cDNA clone expression plasmid, C-Myc tagHuman 4E-BP1/EIF4EBP1 Gene ORF cDNA clone expression plasmid, C-His tagHuman 4E-BP1/EIF4EBP1 Gene ORF cDNA clone expression plasmidRat 4E-BP1/EIF4EBP1 Gene ORF cDNA clone in cloning vectorMouse 4E-BP1/EIF4EBP1 Gene ORF cDNA clone expression plasmid, C-HA tagMouse 4E-BP1/EIF4EBP1 Gene ORF cDNA clone expression plasmid, C-His tagMouse 4E-BP1/EIF4EBP1 Gene ORF cDNA clone expression plasmid, N-Flag tagMouse 4E-BP1/EIF4EBP1 Gene ORF cDNA clone in cloning vectorHuman 4E-BP1/EIF4EBP1 Gene ORF cDNA clone expression plasmid, C-Flag tagMouse 4E-BP1/EIF4EBP1 Gene ORF cDNA clone expression plasmid, C-Flag tagMouse 4E-BP1/EIF4EBP1 Gene ORF cDNA clone expression plasmidMouse 4E-BP1/EIF4EBP1 Gene ORF cDNA clone expression plasmid, C-GFPSpark tagHuman 4E-BP1/EIF4EBP1 Gene ORF cDNA clone expression plasmid, N-Myc tag

4E-BP1/EIF4EBP1 ELISA

Product nameProduct name
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"