4E-BP1 Protein (EIF4EBP1 Protein)

Eukaryotic translation initiation factor 4E binding protein 1

4E-BP1 Products

4E-BP1 Protein, Recombinant

Molecule	Species	Description	Cat. No
4E-BP1/4EBP1/EIF4EBP1	Human	4E-BP1/EIF4EBP1 Protein, Recombinant	10022-H07E

4E-BP1 cDNA Clone

Molecule	Species	Description	Cat. No
4E-BP1/4EBP1/EIF4EBP1	Human	Homo sapiens 4E-BP1/EIF4EBP1 cDNA Clone	HG10022-M
4E-BP1/4EBP1/EIF4EBP1	Mouse	Mouse 4E-BP1/EIF4EBP1 cDNA Clone / ORF Clone	MG50739-G

4E-BP1 Related Areas

Signal Transduction>>Translational Regulator>>4E-BP1/4EBP1/EIF4EBP1

4E-BP1 Alternative Names

4E-BP1, 4EBP1, EIF4EBP1, BP-1, MGC4316, PHAS-I [Homo sapiens]

4e-bp1, Eif4ebp1, AA959816, PHAS-I [Mus musculus]

4E-BP1 Background

The translational suppressor eIF4E binding protein-1, 4E-BP1 functions as a key regulator in cellular growth, differentiation, apoptosis and survival. The Eif4ebp1 gene, encoding 4E-BP1, is a direct target of a transcription factor activating transcription factor-4 (ATF4), a master regulator of gene expression in stress responses. 4E-BP1 is characterized by its capacity to bind specifically to eIF4E and inhibit its interaction with eIF4G. Phosphorylation of 4E-BP1 regulates eIF4E availability, and therefore, cap-dependent translation, in cell stress. Binding of eIF4E to eIF4G is inhibited in a competitive manner by 4E-BP1. Phosphorylation of 4E-BP1 decreases the affinity of this protein for eIF4E, thus favouring the binding of eIF4G and enhancing translation. 4E-BP1 is important for beta-cell survival under endoplasmic reticulum (ER) stress. 4E-BP1 mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways. Recently, 4E-BP1 was found to be a key factor, which converges several oncogenic signals, phosphorylates the molecules, and drives the downstream proliferative signals. Recent studies showed that high expression of phosphorylated 4E-BP-1 (p-4E-BP1) is associated with poor prognosis, tumor progression, or nodal metastasis in different human cancers.

4E-BP1 Related Studies

1. Azar R, et al. (2008) Phosphatidylinositol 3-kinase-dependent transcriptional silencing of the translational repressor 4E-BP1. Cell Mol Life Sci. 65(19): 3110-7.
2. Tominaga R, et al. (2010) The JNK pathway modulates expression and phosphorylation of 4E-BP1 in MIN6 pancreatic beta-cells under oxidative stress conditions. Cell Biochem Funct. 28(5): 387-93.
3. Ayuso MI, et al. (2010) New hierarchical phosphorylation pathway of the translational repressor eIF4E-binding protein 1 (4E-BP1) in ischemia-reperfusion stress. J Biol Chem. 285(45): 34355-63.