4-1BBL Protein & Antibody (CD137L, TNFSF9)

4-1BB Ligand (CD 137 Ligand, Tumor Necrosis Factor (ligand) Superfamily, member 9)

4-1BBL Protein & Antibody

4-1BBL Protein, Recombinant

Molecule	Species	Description	Cat. No
4-1BBL/CD137L	Mouse	4-1BBL/CD137L Protein, Recombinant	50067-M07H

  50067-M07H: Immobilized recombinant mouse 4-1BB Ligand at 20 µg/ml (100µl/well) can bind human 4-1BB with a linear range of 15.6-500 ng/ml. Measured by its binding ability in a functional ELISA.

4-1BBL Antibody

Molecule	Application	Description	Cat. No
Mouse 4-1BBL/CD137L	WB, ELISA	Rabbit Monoclonal Antibody	50067-R014
Mouse 4-1BBL/CD137L	ELISA	Rabbit Polyclonal Antibody	50067-RP01
Mouse 4-1BBL/CD137L	WB, ELISA	Rabbit Polyclonal Antibody	50067-RP02

4-1BBL Related Areas

Immunology>>Adaptive Immunity>>Costimulation & Costimulatory Molecule>>4-1BBL/CD137L/TNFSF9

Immunology>>Cytokine & Receptor>>TNF Superfamily>>4-1BBL/CD137L/TNFSF9

Immunology>>Cluster of Differentiation>>B Cell CD Antigen>>4-1BBL/CD137L/TNFSF9

4-1BBL Alternative Names

4-1BB-L, CD137L, TNFSF9 [Homo sapiens]

4-1BBL, Cd137l, Tnfsf9, 4-1BB-L, AI848817, Ly63l [Mus musculus]

4-1BBL Background

4-1BBL is the high affinity ligand of 4-1BB, also known as CD137L or TNFSF9. It is shown to be a type II surface glycoprotein belonging to the TNF superfamily. Expression of 4-1BBL is restricted to APCs, such as dendritic cells, macrophages, and activated B cells. Members of the TNF-TNF receptor superfamily have been shown to play critical roles in regulating cellular activation, differentiation and apoptosis. Several studies have reported that 4-1BBL/4-1BB interaction provided a co-stimulatory signal to T cells, and increased T cell proliferation and cytokines production. In additon, 4-1BBL is involved in cancers, infectious diseases and autoimmune diseases.

4-1BBL Related Studies

1. Cheung CT, (2007) Neutralizing anti-4-1BBL treatment improves cardiac function in viral myocarditis. Lab Invest. 87(7): 651-61.
2. Wang C, et al. (2009) Immune regulation by 4-1BB and 4-1BBL: complexities and challenges. Immunol Rev. 229(1): 192-215.
3. Habib-Agahi M, et al. (2009) 4-1BBL costimulation retrieves CD28 expression in activated T cells. Cell Immunol. 256(1-2): 39-46.