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2B4 / CD244  Antibody

All CD244 Reagents

Reactivity: Human  
Application: ELISA  
    10042-RP01-400
    10042-RP01-200
    10042-RP01-100
    400 µg 
    200 µg 
    100 µg 
    Add to Cart
    Reactivity: Human  
    Application: ELISA  
      10042-RP02-50
      10042-RP02-200
      10042-RP02-100
      50 µg 
      200 µg 
      100 µg 
      Add to Cart
      Reactivity: Human  
      Application: ELISA  
        10042-MM02-50
        10042-MM02-200
        10042-MM02-100
        50 µg 
        200 µg 
        100 µg 
        Add to Cart
        Reactivity: Human  
        Application: ELISA  
          10042-R020-50
          10042-R020-100
          50 µg 
          100 µg 
          Add to Cart
          Reactivity: Human  
          Application: WB  IP  
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          10042-R025-50
          10042-R025-100
          50 µg 
          100 µg 
          Add to Cart

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            2B4 / CD244 Summary & Protein Information

            2B4 / CD244 Background

            Gene Summary: This gene encodes a cell surface receptor expressed on natural killer (NK) cells (and some T cells) that mediate non-major histocompatibility complex (MHC) restricted killing. The interaction between NK-cell and target cells via this receptor is thought to modulate NK-cell cytolytic activity. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
            General information above from NCBI
            Subunit structure: Interacts with CD48. Following phosphorylation, it is able to recruit PTPN11/SHP-2 and SH2D1A/SAP. Binding of SH2D1A/SAP to CD244 prevents its association with PTPN11/SHP-2.
            Subcellular location: Membrane; Single-pass type I membrane protein (Potential).
            Tissue specificity: Expressed in spleen, PBL, followed by lung, liver, testis and small intestine. Expressed not only in NK cells, but also on monocytes and basophils.
            Post-translational: N-linked glycosylation is essential for the binding to its ligand CD48. Also O-glycosylated, in contrast, O-linked sialylation has a negative impact on ligand binding.
            Sequence similarity: Contains 2 Ig-like (immunoglobulin-like) domains.C
            General information above from UniProt

            The CD244 antigen, also known as 2B4, is a cell surface glycoprotein implicated in the regulation of natural killer and T lymphocyte function. 2B4 is a member of the signaling lymphocyte activation molecule (SLAM)-related receptor family and is important for stimulating NK cell cytotoxicity and cytokine production, which is expressed on all NK cells, a subpopulation of T cells, monocytes and basophils. The 2B4 antigen identified on NK cells and T cells is capable of transmitting stimulatory signals and non-MHC-restricted killing. Reported as an activating receptor, human 2B4 can effectively activate and enhance NK cell–mediated cytotoxicity, induce secretion of IFN-γ and matrix metalloproteinases (MMPs), as well as NK cell invasiveness. As a cell surface glycoprotein of the Ig-superfamily structurally related to CD2-like molecules such as CD2, CD48, CD58, CD84, Ly-9, and SLAM, 2B4 (CD244) is expressed on all human NK cells, a subpopulation of T cells, basophils and monocytes. 2B4 activates NK cell mediated cytotoxicity, induces secretion of IFN-gamma and matrix metalloproteinases, and NK cell invasiveness.

            Immune Checkpoint
            Immune Checkpoint Detection: AntibodiesImmune Checkpoint Detection: ELISA AntibodiesImmune Checkpoint Detection: IP AntibodiesImmune Checkpoint Detection: FCM Antibodies
            Immune Checkpoint Proteins
            Immune Checkpoint TargetsCo-inhibitory Immune Checkpoint Targets

            2B4 / CD244 Alternative Name

            2B4 / CD244 Related Studies

          • Nakajima H, et al. (2000) 2B4: an NK cell activating receptor with unique specificity and signal transduction mechanism. Hum Immunol. 61(1): 39-43.
          • Chuang SS, et al. (2001) 2B4 (CD244)-mediated activation of cytotoxicity and IFN-gamma release in human NK cells involves distinct pathways. J Immunol. 167(11): 6210-6.
          • McNerney ME, et al. (2005) 2B4 (CD244) is a non-MHC binding receptor with multiple functions on natural killer cells and CD8+ T cells. Mol Immunol. 42(4): 489-94.
          • Mathew SO, et al. (2009) Functional role of human NK cell receptor 2B4 (CD244) isoforms. Eur J Immunol. 39(6): 1632-41.
          • Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"