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> 2B4 Protein & Antibody (CD244, SLAMF4) 2B4 Protein & Antibody (CD244, SLAMF4)
Cluster of Differentiation 244, Signaling Lymphocytic Activation Molecule 4
2B4 Products
2B4 Protein, Recombinant
| Molecule | Species | Description //For Detailed Info. and Price------CLICK! | Cat. No |
| 2B4/CD244/SLAMF4 | Human | 2B4/CD244/SLAMF4/Fc Protein, Recombinant |
10042-H02H |
| 2B4/CD244/SLAMF4 | Human | 2B4/CD244/SLAMF4 Protein, Recombinant |
10042-H08H |
2. Measured by its ability to bind biotinylated mouse CD48 in a functional ELISA.
2B4 Antibody
| Molecule | Application | Description //For Detailed Info. and Price------CLICK! | Cat. No |
| Human 2B4/CD244/SLAMF4 |
WB, ELISA | 2B4/CD244/SLAMF4 Antibody, Rabbit PAb | 10042-RP01 |
| Human 2B4/CD244/SLAMF4 |
WB, ELISA | 2B4/CD244/SLAMF4 Antibody, Rabbit PAb (Antigen Affinity Purified) | 10042-RP02 |
2B4 cDNA Clone
| Molecule | Species | Description //For Detailed Info. and Price------CLICK! | Cat. No |
| 2B4/CD244/SLAMF4 | Human | Homo sapiens 2B4/CD244/SLAMF4 cDNA Clone(NM_016382.2) | HG10042-M |
2B4 Related Areas
Immunology>>Adaptive Immunity>>Costimulation & Costimulatory Molecule>>2B4/CD244/SLAMF4
Immunology>>Innate Immunity>>Natural Killer Cell (NK Cell)>>2B4/CD244/SLAMF4
Immunology>>Cluster of Differentiation>>B Cell CD Antigen>>2B4/CD244/SLAMF4
Immunology>>Cluster of Differentiation>>Granulocyte CD Antigen>>Basophils>>2B4/CD244/SLAMF4
Immunology>>Cluster of Differentiation>>Monocyte/Macrophage CD Antigen>>Monocyte Markers>>2B4/CD244/SLAMF4
Immunology>>Cluster of Differentiation>>Natural Killer (NK) Cell CD Antigen>>2B4/CD244/SLAMF4
2B4 Alternative Names
2B4, CD244, SLAMF4, NAIL, NKR2B4, Nmrk [Homo sapiens]
2B4, Cd244, SLAMF4, C9.1, F730046O15Rik, Ly90, NAIL, NKR2B4, Nmrk [Mus musculus]
2B4 Related Products
Protein Products
| Molecule | Species | Description //For Detailed Info. and Price------CLICK! |
| CD150/SLAM | Human | CD150/SLAM Protein, Recombinant |
| CD48/SLAMF2 | Human | CD48/SLAMF2 Protein, Recombinant |
| CD48/SLAMF2 | Mouse | CD48 Protein, Recombinant |
| Ly9/CD229/SLAMF3 | Mouse | LY9/CD229/SLAMF3 Protein, Recombinant |
| 2B4/CD244/SLAMF4 | Human | 2B4/CD244/SLAMF4/Fc Protein, Recombinant |
| CD84/SLAMF5 | Human | CD84/SLAMF5 Protein, Recombinant |
| Ly108/SLAMF6 | Human | Ly108/SLAMF6 Protein, Recombinant |
| Ly108/SLAMF6 | Mouse | Ly108/SLAMF6 Protein, Recombinant |
| CRACC/SLAMF7 | Human | CRACC/SLAMF7 Protein, Recombinant |
| CRACC/SLAMF7 | Mouse | CRACC/SLAMF7 Protein, Recombinant |
| SLAMF8 | Mouse | SLAMF8 Protein, Recombinant |
Antibody Products
cDNA Clone Products
| Molecule | Species | Description //For Detailed Info. and Price------CLICK! |
| CD150/SLAM | Human | Homo sapiens CD150/SLAM cDNA Clone(NM_003037.2) |
| CD48/SLAMF2 | Human | Homo sapiens CD48/SLAMF2 cDNA Clone(NM_001778.2) |
| CD48/SLAMF2 | Mouse | Mus musculus CD48 cDNA Clone |
| Ly9/CD229/SLAMF3 | Mouse | Mus musculus LY9/CD229/SLAMF3 cDNA Clone |
| CD84/SLAMF5 | Human | Homo sapiens CD84/SLAMF5 cDNA Clone(NM_003874.2) |
| Ly108/SLAMF6 | Mouse | Mus musculus Ly108/SLAMF6 cDNA Clone |
| CRACC/SLAMF7 | Human | Homo sapiens CRACC/SLAMF7 cDNA Clone |
| CRACC/SLAMF7 | Mouse | Mus musculus CRACC/SLAMF7 cDNA Clone |
| SLAMF8 | Human | Homo sapiens SLAMF8 cDNA Clone |
| SLAMF8 | Mouse | Mus musculus SLAMF8 cDNA Clone |
2B4 Background
The CD244 antigen, also known as 2B4, is a cell surface glycoprotein implicated in the regulation of natural killer and T lymphocyte function. 2B4 is a member of the signaling lymphocyte activation molecule (SLAM)-related receptor family and is important for stimulating NK cell cytotoxicity and cytokine production, which is expressed on all NK cells, a subpopulation of T cells, monocytes and basophils. The 2B4 antigen identified on NK cells and T cells is capable of transmitting stimulatory signals and non-MHC-restricted killing. Reported as an activating receptor, human 2B4 can effectively activate and enhance NK cell–mediated cytotoxicity, induce secretion of IFN-γ and matrix metalloproteinases (MMPs), as well as NK cell invasiveness. As a cell surface glycoprotein of the Ig-superfamily structurally related to CD2-like molecules such as CD2, CD48, CD58, CD84, Ly-9, and SLAM, 2B4 (CD244) is expressed on all human NK cells, a subpopulation of T cells, basophils and monocytes. 2B4 activates NK cell mediated cytotoxicity, induces secretion of IFN-gamma and matrix metalloproteinases, and NK cell invasiveness.
2B4 Related Studies
- Nakajima H, et al. (2000) 2B4: an NK cell activating receptor with unique specificity and signal transduction mechanism. Hum Immunol. 61(1): 39-43.
- Chuang SS, et al. (2001) 2B4 (CD244)-mediated activation of cytotoxicity and IFN-gamma release in human NK cells involves distinct pathways. J Immunol. 167(11): 6210-6.
- McNerney ME, et al. (2005) 2B4 (CD244) is a non-MHC binding receptor with multiple functions on natural killer cells and CD8+ T cells. Mol Immunol. 42(4): 489-94.
- Mathew SO, et al. (2009) Functional role of human NK cell receptor 2B4 (CD244) isoforms. Eur J Immunol. 39(6): 1632-41.
