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2B4 / SLAMF4 / CD244 Antibody, Rabbit PAb, Antigen Affinity Purified

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    Human 2B4/SLAMF4 Antibody Product Information
    Immunogen:Recombinant Human 2B4 protein (Catalog#10042-H08H)
    Clone ID:
    Ig Type:Rabbit IgG
    Concentration:
    Formulation:0.2 μm filtered solution in PBS with 5% trehalose
    Preparation:Produced in rabbits immunized with purified, recombinant Human 2B4 (rh 2B4; Catalog#10042-H08H; NP_057466.1; Met 1-Arg 221). 2B4 specific IgG was purified by human 2B4 affinity chromatography .
    Other 2B4/SLAMF4 Antibody Products
    Reactivity: Human  
    Application: ELISA  
      10042-RP01-400
      10042-RP01-100
      10042-RP01-200
       
      100 µg 
      200 µg 
      Add to Cart
      Reactivity: Human  
      Application: ELISA  
        10042-MM02-200
        10042-MM02-50
        10042-MM02-100
        200 µg 
        50 µg 
        100 µg 
        Add to Cart
        Reactivity: Human  
        Application: ELISA  
          10042-R020-50
          10042-R020-100
          50 µg 
          100 µg 
          Add to Cart
          Reactivity: Human  
          Application: WB  IP  
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          10042-R025-100
          10042-R025-50
          100 µg 
          50 µg 
          Add to Cart
          2B4 / CD244 Background

          The CD244 antigen, also known as 2B4, is a cell surface glycoprotein implicated in the regulation of natural killer and T lymphocyte function. 2B4 is a member of the signaling lymphocyte activation molecule (SLAM)-related receptor family and is important for stimulating NK cell cytotoxicity and cytokine production, which is expressed on all NK cells, a subpopulation of T cells, monocytes and basophils. The 2B4 antigen identified on NK cells and T cells is capable of transmitting stimulatory signals and non-MHC-restricted killing. Reported as an activating receptor, human 2B4 can effectively activate and enhance NK cell–mediated cytotoxicity, induce secretion of IFN-γ and matrix metalloproteinases (MMPs), as well as NK cell invasiveness. As a cell surface glycoprotein of the Ig-superfamily structurally related to CD2-like molecules such as CD2, CD48, CD58, CD84, Ly-9, and SLAM, 2B4 (CD244) is expressed on all human NK cells, a subpopulation of T cells, basophils and monocytes. 2B4 activates NK cell mediated cytotoxicity, induces secretion of IFN-gamma and matrix metalloproteinases, and NK cell invasiveness.

          Immune Checkpoint
          Immune Checkpoint Detection: Antibodies   Immune Checkpoint Detection: ELISA Antibodies   Immune Checkpoint Detection: IP Antibodies   Immune Checkpoint Detection: FCM Antibodies
          Immune Checkpoint Proteins
          Immune Checkpoint Targets   Co-inhibitory Immune Checkpoint Targets

          Immunotherapy   Cancer Immunotherapy   Targeted Therapy

          Human 2B4 / CD244 References
        • Nakajima H, et al. (2000) 2B4: an NK cell activating receptor with unique specificity and signal transduction mechanism. Hum Immunol. 61(1): 39-43.
        • Chuang SS, et al. (2001) 2B4 (CD244)-mediated activation of cytotoxicity and IFN-gamma release in human NK cells involves distinct pathways. J Immunol. 167(11): 6210-6.
        • McNerney ME, et al. (2005) 2B4 (CD244) is a non-MHC binding receptor with multiple functions on natural killer cells and CD8+ T cells. Mol Immunol. 42(4): 489-94.
        • Mathew SO, et al. (2009) Functional role of human NK cell receptor 2B4 (CD244) isoforms. Eur J Immunol. 39(6): 1632-41.
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          Size / Price
          Catalog: 10042-RP02-200
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          Datasheet & Documentation

          All information of our products is subject to change without notice. Please refer to COA enclosed in shipped package for the newest information.
          Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"