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YWHAQ Protein, Antibody, ELISA Kit, cDNA Clone

YWHAQ Related Areas

YWHAQ Related Pathways

YWHAQ Related Product

    YWHAQ Summary & Protein Information

    YWHAQ Background

    Gene Summary: This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse and rat orthologs. This gene is upregulated in patients with amyotrophic lateral sclerosis. It contains in its 5' UTR a 6 bp tandem repeat sequence which is polymorphic, however, there is no correlation between the repeat number and the disease.
    General information above from NCBI
    Subunit structure: Homodimer. Interacts with CDK16 (By similarity). Interacts with SSH1. Interacts with CDKN1B ('Thr-198' phosphorylated form); the interaction translocates CDKN1B to the cytoplasm. Interacts with GAB2. Interacts with the 'Ser-241' phosphorylated form of PDPK1.
    Subcellular location: Cytoplasm. Note=In neurons, axonally transported to the nerve terminals.
    Tissue specificity: Abundantly expressed in brain, heart and pancreas, and at lower levels in kidney and placenta. Up-regulated in the lumbar spinal cord from patients with sporadic amyotrophic lateral sclerosis (ALS) compared with controls, with highest levels of expression in individuals with predominant lower motor neuron involvement.
    Post-translational: Ser-232 is probably phosphorylated by CK1.
    Sequence similarity: Belongs to the 14-3-3 family.C
    General information above from UniProt

    YWHAQ Alternative Name

    14-3-3 tau,1C5,HS1,14-3-3 theta,YWHAQ, [human]
    14-3-3 tau,MGC118161,R74690,14-3-3 theta,2700028P07Rik,AA409740,AU021156,Ywhaq, [mouse]

    YWHAQ Related Studies

  • Cheng Y, et al. (2010) Effect of 14-3-3 tau protein on differentiation in BeWo choriocarcinoma cells. Placenta. 31(1): 60-6.
  • Umahara T, et al. (2010) 14-3-3 proteins and spinocerebellar ataxia type 1: from molecular interaction to human neuropathology. Cerebellum. 9(2): 183-9.
  • Wang B, et al. (2004) A role for 14-3-3 tau in E2F1 stabilization and DNA damage-induced apoptosis. J Biol Chem. 279(52): 54140-52.
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