14-3-3 tau / 14-3-3 theta / YWHAQ Protein

Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide

14-3-3 tau / 14-3-3 theta / YWHAQ Products

14-3-3 tau / 14-3-3 theta / YWHAQ Protein, Recombinant

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
14-3-3 tau/14-3-3 theta/YWHAQ	Human	YWHAQ/14-3-3 tau/14-3-3 theta Protein, Recombinant, with GST Tag	10845-H09E

14-3-3 tau / 14-3-3 theta / YWHAQ cDNA Clone

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
14-3-3 tau/14-3-3 theta/YWHAQ	Human	Human 14-3-3 tau/14-3-3 theta/YWHAQ cDNA Clone / ORF Clone	HG10845-M
14-3-3 tau/14-3-3 theta/YWHAQ	Human	Human YWHAQ ORF Expression Clone, HA-tagged	HG10845-M-Y

14-3-3 tau / 14-3-3 theta / YWHAQ Related Areas

Cancer>>Apoptosis>>Death Receptor & Ligand>>14-3-3 tau/14-3-3 theta/YWHAQ

Signal Transduction>>Adaptor Protein>>14-3-3 tau/14-3-3 theta/YWHAQ

14-3-3 tau / 14-3-3 theta / YWHAQ Alternative Names

14-3-3 tau, 14-3-3 theta,YWHAQ, 14-3-3, 1C5, HS1 [Homo sapiens]

14-3-3 tau, 14-3-3 theta, Ywhaq, 2700028P07Rik, AA409740, AU021156, MGC118161, R74690 [Mus musculus]

14-3-3 tau / 14-3-3 theta / YWHAQ Related Products

Protein Products

Molecule	Species	Description //For Detailed Info. and Price------CLICK!
14-3-3 beta/YWHAB	Human	14-3-3 beta/YWHAB Protein, Recombinant, With GST Tag
14-3-3 beta/YWHAB	Human	14-3-3 beta/YWHAB Protein, Recombinant
14-3-3 epsilon/YWHAE	Human	14-3-3 epsilon/YWHAE Protein, Recombinant, With GST Tag
14-3-3 epsilon/YWHAE	Human	14-3-3 epsilon/YWHAE Protein, Recombinant
14-3-3 epsilon/YWHAE	Mouse	14-3-3 epsilon/YWHAE Protein, Recombinant, with GST Tag
14-3-3 eta/YWHAH	Human	14-3-3 eta/YWHAH Protein, Recombinant, GST Tag
14-3-3 sigma/Stratifin/YWHAS	Human	14-3-3 sigma/Stratifin/YWHAS Protein, Recombinant, With GST Tag
14-3-3 sigma/Stratifin/YWHAS	Human	14-3-3 sigma/Stratifin/YWHAS Protein, Recombinant
14-3-3 sigma/Stratifin/YWHAS	Mouse	14-3-3 sigma/Stratifin/YWHAS Protein, Recombinant

cDNA Clone Products

Molecule	Species	Description //For Detailed Info. and Price------CLICK!
14-3-3 epsilon/YWHAE	Human	Homo sapiens 14-3-3 epsilon/YWHAE cDNA Clone(NM_006761.4)
14-3-3 epsilon/YWHAE	Mouse	Mouse 14-3-3 epsilon/YWHAE cDNA Clone / ORF Clone
14-3-3 epsilon/YWHAE	Rat	Rat 14-3-3 epsilon/YWHAE cDNA Clone / ORF Clone
14-3-3 beta/YWHAB	Human	Homo sapiens 14-3-3 beta/YWHAB cDNA Clone(NM_003404.3)
14-3-3 gamma/YWHAG	Human	Homo sapiens 14-3-3 gamma/YWHAG cDNA Clone(NM_012479.3)
14-3-3 eta/YWHAH	Human	Human 14-3-3 eta/YWHAH cDNA Clone / ORF Clone
14-3-3 eta/YWHAH	Mouse	Mouse 14-3-3 eta/YWHAH cDNA Clone / ORF Clone
14-3-3 sigma/Stratifin/YWHAS	Human	Homo sapiens 14-3-3 sigma/Stratifin/YWHAS cDNA Clone(NM_006142.3)
14-3-3 sigma/Stratifin/YWHAS	Mouse	Mus musculus 14-3-3 sigma/Stratifin/YWHAS cDNA Clone

14-3-3 tau / 14-3-3 theta / YWHAQ Background

YWHAQ, also known as 14-3-3 tau, or 14-3-3 theta, which mediate signal transduction by binding to phosphoserine-containing proteins. 14-3-3 tau/14-3-3 theta/YWHAQ is a member of the 14-3-3 proteins family. 14-3-3 proteins are mainly localized in the synapses and neuronal cytoplasm, and seven isoforms have been identified in mammals. This family of proteins was initially identified as adaptor proteins which bind to phosphoserine-containing motifs. Binding motifs and potential functions of 14-3-3 proteins are now recognized to have a wide range of functional relevance. 14-3-3 tau, a phosphoserine-binding protein, mediates E2F1 stabilization. 14-3-3 tau interacts with ATM-phosphorylated E2F1 during DNA damage and inhibits E2F1 ubiquitination. Depletion of 14-3-3 tau or E2F1, but not E2F2 or E2F3, blocks adriamycin-induced apoptosis. 14-3-3 tau is also required for expression and induction of E2F1 apoptotic targets, such as p73, Apaf-1, and caspases, during DNA damage. Additionally, 14-3-3 tau might be mediated trophoblast differentiation through cell cycle regulation.

14-3-3 tau / 14-3-3 theta / YWHAQ Related Studies

1. Cheng Y, et al. (2010) Effect of 14-3-3 tau protein on differentiation in BeWo choriocarcinoma cells. Placenta. 31(1): 60-6.
2. Umahara T, et al. (2010) 14-3-3 proteins and spinocerebellar ataxia type 1: from molecular interaction to human neuropathology. Cerebellum. 9(2): 183-9.
3. Wang B, et al. (2004) A role for 14-3-3 tau in E2F1 stabilization and DNA damage-induced apoptosis. J Biol Chem. 279(52): 54140-52.