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14-3-3 sigma/Stratifin/YWHAS  Antibody

All YWHAS Reagents

Reactivity: Human  
Application: 
10838-T54-50
10838-T54-200
10838-T54-100
50 µg 
200 µg 
100 µg 
Add to Cart
  • Slide 1
  • Slide 1
  • Slide 1
Reactivity: Human  
Application: ELISA  
10838-RP01-400
10838-RP01-200
10838-RP01-100
400 µg 
200 µg 
100 µg 
Add to Cart
    Reactivity: Human  
    Application: ELISA  
    10838-RP02-50
    10838-RP02-200
    10838-RP02-100
    50 µg 
    200 µg 
    100 µg 
    Add to Cart
      Reactivity: Human  
      Application: FCM  
      10838-MM02-P-25
      10838-MM02-P-100
      25 Test 
      100 Tests 
      Add to Cart
      • Slide 1
      Reactivity: Human  
      Application: FCM  
      10838-MM02-50
      10838-MM02-200
      10838-MM02-100
      50 µg 
      200 µg 
      100 µg 
      Add to Cart
      • Slide 1
      Reactivity: Mouse  
      Application: ELISA  WB  IHC-P  IP  
      50576-RP02-50
      50576-RP02-200
      50576-RP02-100
      50 µg 
      200 µg 
      100 µg 
      Add to Cart
      • Slide 1
      • Slide 1
      • Slide 1
      Reactivity: Mouse  
      Application: ELISA  
      50576-RP01-400
      50576-RP01-200
      50576-RP01-100
      400 µg 
      200 µg 
      100 µg 
      Add to Cart

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          14-3-3 sigma/Stratifin/YWHAS Summary & Protein Information

          14-3-3 sigma/Stratifin/YWHAS Background

          Gene Summary: OMIM - description for 14-3-3 sigma (Stratifin, YWHAS):
          General information above from NCBI
          Subunit structure: Homodimer. Interacts with KRT17 and SAMSN1 (By similarity). Found in a complex with XPO7, EIF4A1, ARHGAP1, VPS26A, VPS29, VPS35 and SFN. Interacts with GAB2. Interacts with SRPK2. Interacts with COPS6. Interacts with RFWD2; this interaction leads to proteasomal degradation. {ECO:0000250, ECO:0000269|PubMed:15282546, ECO:0000269|PubMed:15731107, ECO:0000269|PubMed:19172738, ECO:0000269|PubMed:19592491, ECO:0000269|PubMed:21625211, ECO:0000269|PubMed:22634725}.
          Subcellular location: Cytoplasm. Nucleus {ECO:0000250}. Secreted. Note=May be secreted by a non-classical secretory pathway.
          Tissue specificity: Present mainly in tissues enriched in stratified squamous keratinizing epithelium.
          Post-translational: Ubiquitinated. Ubiquitination by RFFL induces proteasomal degradation and indirectly regulates p53/TP53 activation. {ECO:0000269|PubMed:18382127}.
          Sequence similarity: Belongs to the 14-3-3 family. {ECO:0000305}.
          General information above from UniProt

          14-3-3 protein sigma (YWHAS), also known as stratifin (SFN) and epithelial cell marker protein 1, is a member of the14-3-3 proteins which are a family of conserved regulatory molecules expressed in all eukaryotic cells. The name 14-3-3 refers to the particular elution and migration pattern of these proteins on DEAE-cellulose chromatography and starch-gel electrophoresis. The 14-3-3 proteins eluted in the 14th fraction of bovine brain homogenate and were found on positions 3.3 of subsequent electrophoresis. There are seven genes that encode 14-3-3s in most mammals. 14-3-3 proteins have been identified as adapter proteins implicated in the regulation of a large spectrum of both general and specialized signaling pathway. More than 100 signaling proteins have been reported as 14-3-3 ligands including kinases, phosphatases, and transmembrane receptors, and the binding generally results in the modulation of the activity of the binding partner. YWHAE exists as a homodimer and present mainly in tissues enriched in stratified squamous keratinising epithelium. YWHAS has been repoted to interact with KRT17 and GAB2, and may regulate protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway upon binding to KRT17. Additionally, YWHAS (SFN) may also act as a p53-regulated inhibitor of G2/M progression.

          14-3-3 sigma/Stratifin/YWHAS Alternative Name

          14-3-3 sigma/Stratifin/YWHAS Related Studies

          Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"