14-3-3 sigma (Stratifin, YWHAS)

Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway By similarity. p53-regulated inhibitor of G2/M progression.

14-3-3 sigma (Stratifin, YWHAS) Related Areas

Cancer>>Apoptosis>>Death Receptor & Ligand>>14-3-3 sigma/Stratifin/YWHAS

Signal Transduction>>Adaptor Protein>>14-3-3 sigma/Stratifin/YWHAS

14-3-3 sigma (Stratifin, YWHAS) Alternative Names

14-3-3 sigma, Stratifin, YWHAS [Homo sapiens]

14-3-3 sigma, Stratifin, Ywhas, RP23-137L22.11, Er, Mme1 [Mus musculus]

Summaries for 14-3-3 sigma (Stratifin, YWHAS)

Entrez Gene summary for 14-3-3 sigma (Stratifin, YWHAS):

OMIM - description for 14-3-3 sigma (Stratifin, YWHAS):

Through a quantitative analysis of gene expression patterns in colorectal cancer cell lines, Hermeking et al. (1997) discovered that 14-3-3-sigma, or stratifin, is strongly induced by gamma irradiation and other DNA-damaging agents. The induction of 14-3-3-sigma is mediated by a p53 (191170)-responsive element located 1.8 kb upstream of its transcription start site. Exogenous introduction of 14-3-3-sigma into cycling cells results in a G2 arrest. As the fission yeast 14-3-3 homologs rad24 and rad25 mediate similar checkpoint effects, Hermeking et al. (1997) concluded that the results document a molecular mechanism for G2/M control that is conserved throughout eukaryotic evolution and regulated in human cells by p53.

Wikipedia summary for 14-3-3 sigma (Stratifin, YWHAS):

14-3-3 protein sigma is a protein that in humans is encoded by the SFN gene

Human 14-3-3 sigma (Stratifin, YWHAS) Protein General Information

 

• Protein names: Recommended name: 14-3-3 protein sigma
• Sequence length: 248 AA.
• Sequence similarities: Belongs to the 14-3-3 family.
• Subunit structure: Homodimer. Interacts with KRT17 and SAMSN1 By similarity. Found in a complex with XPO7, EIF4A1, ARHGAP1, VPS26A, VPS29, VPS35 and SFN. Interacts with GAB2. Interacts with SRPK2
• Subcellular location: Cytoplasm. Nucleus By similarity. Secreted. Note: May be secreted by a non-classical secretory pathway.
• Tissue specificity: Present mainly in tissues enriched in stratified squamous keratinizing epithelium.

General information above from UniProt

Function for 14-3-3 sigma (Stratifin, YWHAS) Protein

UniProtKB:

Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway By similarity. p53-regulated inhibitor of G2/M progression.

Genatlas:

• 14-3-3 sigma may be involved in negative regulation of protein kinase activity, cell proliferation, signal transduction, regulation of cell cycle
• 14-3-3 sigma is implicated in G2/M cell cycle arrest by Tp53
• 14-3-3 sigma having function linked to epidermal stratification and differentiation in the skin
• The critical of 14-3-3 sigma for regulating corneal epithelial proliferation and differentiation by regulating Notch signaling activity
• important G2M cell cycle checkpoint regulator and its expression is induced by DNA damage stress through a TP53-dependent pathway
• The regulates of 14-3-3 sigma corneal epithelial cell proliferation and differentiation by maintaining Notch activity
• 14-3-3 sigmaplays a critical role in retaining epithelial polarity, through its interaction with PARD3

Homology for human 14-3-3 sigma (Stratifin, YWHAS)

• homolog to murine Mkrn3