14-3-3 eta / YWHAH Protein

Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide

14-3-3 eta / YWHAH Products

14-3-3 eta / YWHAH Protein, Recombinant

Molecule	Species	Description	Cat. No
14-3-3 eta/YWHAH	Human	14-3-3 eta/YWHAH Protein, Recombinant, with GST Tag	10847-H09E

14-3-3 eta / YWHAH cDNA Clone

Molecule	Species	Description	Cat. No
14-3-3 eta/YWHAH	Human	Human 14-3-3 eta/YWHAH cDNA Clone / ORF Clone	HG10847-M
14-3-3 eta/YWHAH	Mouse	Mouse 14-3-3 eta/YWHAH cDNA Clone / ORF Clone	MG50864-G

14-3-3 eta / YWHAH Related Areas

Cancer>>Apoptosis>>Death Receptor & Ligand>>14-3-3 eta/YWHAH

Signal Transduction>>Adaptor Protein>>14-3-3 eta/YWHAH

14-3-3 eta / YWHAH Alternative Names

14-3-3 eta, YWHAH, LL22NC03-44A4.1, YWHA1[Homo sapiens]

14-3-3 eta, Ywhah, 14-3-3 protein eta; OTTMUSP00000017560 [Mus musculus]

14-3-3 eta / YWHAH Related Products

Protein Products

Molecule	Species	Description //For Detailed Info. and Price------CLICK!
14-3-3 beta/YWHAB	Human	14-3-3 beta/YWHAB Protein, Recombinant, With GST Tag
14-3-3 beta/YWHAB	Human	14-3-3 beta/YWHAB Protein, Recombinant
14-3-3 epsilon/YWHAE	Human	14-3-3 epsilon/YWHAE Protein, Recombinant, With GST Tag
14-3-3 epsilon/YWHAE	Human	14-3-3 epsilon/YWHAE Protein, Recombinant
14-3-3 epsilon/YWHAE	Mouse	14-3-3 epsilon/YWHAE Protein, Recombinant, with GST Tag
14-3-3 tau/14-3-3 theta/YWHAQ	Human	YWHAQ/14-3-3 tau/14-3-3 theta Protein, Recombinant, GST Tag
14-3-3 sigma/Stratifin/YWHAS	Human	14-3-3 sigma/Stratifin/YWHAS Protein, Recombinant, With GST Tag
14-3-3 sigma/Stratifin/YWHAS	Human	14-3-3 sigma/Stratifin/YWHAS Protein, Recombinant
14-3-3 sigma/Stratifin/YWHAS	Mouse	14-3-3 sigma/Stratifin/YWHAS Protein, Recombinant

cDNA Clone Products

Molecule	Species	Description //For Detailed Info. and Price------CLICK!
14-3-3 epsilon/YWHAE	Human	Homo sapiens 14-3-3 epsilon/YWHAE cDNA Clone(NM_006761.4)
14-3-3 epsilon/YWHAE	Mouse	Mouse 14-3-3 epsilon/YWHAE cDNA Clone / ORF Clone
14-3-3 epsilon/YWHAE	Rat	Rat 14-3-3 epsilon/YWHAE cDNA Clone / ORF Clone
14-3-3 beta/YWHAB	Human	Homo sapiens 14-3-3 beta/YWHAB cDNA Clone(NM_003404.3)
14-3-3 gamma/YWHAG	Human	Homo sapiens 14-3-3 gamma/YWHAG cDNA Clone(NM_012479.3)
14-3-3 tau/14-3-3 theta/YWHAQ	Human	Human 14-3-3 tau/14-3-3 theta/YWHAQ cDNA Clone / ORF Clone
14-3-3 sigma/Stratifin/YWHAS	Human	Homo sapiens 14-3-3 sigma/Stratifin/YWHAS cDNA Clone(NM_006142.3)
14-3-3 sigma/Stratifin/YWHAS	Mouse	Mus musculus 14-3-3 sigma/Stratifin/YWHAS cDNA Clone

14-3-3 eta / YWHAH Background

YWHAH (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide), also known as 14-3-3 eta, belongs to the 14-3-3 family. 14-3-3 proteins are abundantly expressed in the brain, particularly neuronal tissue and are thought to serve multiple biological functions involved in neuronal development and cell growth and death. Recent studies have shown associations of 14-3-3 genes with neurodegenerative disorders based on their chromosomal linkage to these diseases and to regulatory functions for the nervous system. In addition, 14-3-3 proteins have recently been found to associate with a number of important signaling proteins, such as protein kinase C and Raf-1, as functional modulators. 14-3-3 eta protein in GR-mediated signaling pathways and also point to a mechanism whereby glucocorticoid receptor (GR) may cross-talk with other signal transduction systems. 14-3-3 eta functions as a positive regulator in the glucocorticoid signal pathway by blocking the degradation of GR and inducing an elevation of GR, thus enhancing the transcriptional activity of GR. YWHAH is also a positional and functional candidate gene for both schizophrenia and bipolar disorder (BP).

14-3-3 eta / YWHAH Related Studies

1. Wakui H, et al. (1997) Interaction of the ligand-activated glucocorticoid receptor with the 14-3-3 eta protein. J Biol Chem. 272(13): 8153-6.
2. Toyooka K, et al. (2002) Isolation and structure of the mouse 14-3-3 eta chain gene and the distribution of 14-3-3 eta mRNA in the mouse brain. Brain Res Mol Brain Res. 100(1-2): 13-20.
3. Kim YS, et al. (2005) Role of 14-3-3 eta as a positive regulator of the glucocorticoid receptor transcriptional activation. Endocrinology. 146(7): 3133-40.
4. Grover D, et al. (2009) Family-based association of YWHAH in psychotic bipolar disorder. Am J Med Genet B Neuropsychiatr Genet. 150B(7): 977-83.