14-3-3 epsilon / YWHAE Protein

Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide

14-3-3 epsilon / YWHAE Products

14-3-3 epsilon / YWHAE Protein, Recombinant

Molecule	Species	Description	Cat. No
14-3-3 epsilon/YWHAE	Human	14-3-3 epsilon/YWHAE Protein, Recombinant, With GST Tag	10842-H09E
14-3-3 epsilon/YWHAE	Human	14-3-3 epsilon/YWHAE Protein, Recombinant	10842-HNCE
14-3-3 epsilon/YWHAE	Mouse	14-3-3 epsilon/YWHAE Protein, Recombinant, with GST Tag	50691-M09E

14-3-3 epsilon / YWHAE cDNA Clone

Molecule	Species	Description	Cat. No
14-3-3 epsilon/YWHAE	Human	Homo sapiens 14-3-3 epsilon/YWHAE cDNA Clone(NM_006761.4)	HG10842-M
14-3-3 epsilon/YWHAE	Mouse	Mouse 14-3-3 epsilon/YWHAE cDNA Clone / ORF Clone	MG50691-G
14-3-3 epsilon/YWHAE	Rat	Rat 14-3-3 epsilon/YWHAE cDNA Clone / ORF Clone	RG80090-G

14-3-3 epsilon / YWHAE Related Areas

Cancer>>Apoptosis>>Death Receptor & Ligand>>14-3-3 epsilon/YWHAE

Signal Transduction>>Adaptor Protein>>14-3-3 epsilon/YWHAE

14-3-3 epsilon / YWHAE Alternative Names

14-3-3 epsilon, YWHAE, 14-3-3E, FLJ45465, FLJ53559, KCIP-1, MDCR, MDS [Homo sapiens]

14-3-3 epsilon, Ywhae, RP23-78H4.1, AU019196 [Mus musculus]

14-3-3 epsilon / YWHAE Background

YWHAE, also known as 14-3-3 epsilon, mediate signal transduction by binding to phosphoserine-containing proteins. 14-3-3 epsilon / YWHAE is a member of the 14-3-3 proteins family. 14-3-3 proteins are a group of highly conserved proteins that are involved in many vital cellular processes such as metabolism, protein trafficking, signal transduction, apoptosis and cell cycle regulation. 14-3-3 proteins are mainly localized in the synapses and neuronal cytoplasm, and seven isoforms have been identified in mammals. This family of proteins was initially identified as adaptor proteins which bind to phosphoserine-containing motifs. Binding motifs and potential functions of 14-3-3 proteins are now recognized to have a wide range of functional relevance. 14-3-3 epsilon / YWHAE is found in both plants and mammals, and this protein is 100% identical to the mouse ortholog. YWHAE interacts with CDC25 phosphatases, RAF1 and IRS1 proteins, suggesting its role in diverse biochemical activities related to signal transduction, such as cell division and regulation of insulin sensitivity. It has also been implicated in the pathogenesis of small cell lung cancer. 14-3-3 epsilon / YWHAE is implicated in the regulation of a large spectrum of both general and specialized signaling pathways. 14-3-3 epsilon / YWHAE Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. This Binding generally results in the modulation of the activity of the binding partner.

14-3-3 epsilon / YWHAE Related Studies

1. Ikeda M, et al. (2008) Identification of YWHAE, a gene encoding 14-3-3epsilon, as a possible susceptibility gene for schizophrenia. Hum Mol Genet. 17(20): 3212-22.
2. Mignon-Ravix C, et al. (2010) Deletion of YWHAE in a patient with periventricular heterotopias and pronounced corpus callosum hypoplasia. J Med Genet. 47(2): 132-6.
3. Nagamani SC, et al. (2009) Microdeletions including YWHAE in the Miller-Dieker syndrome region on chromosome 17p13.3 result in facial dysmorphisms, growth restriction, and cognitive impairment. J Med Genet. 46(12): 825-33.

14-3-3 epsilon / YWHAE Related Products

Protein Products

Molecule	Species	Description //For Detailed Info. and Price------CLICK!
14-3-3 beta/YWHAB	Human	14-3-3 beta/YWHAB Protein, Recombinant, With GST Tag
14-3-3 beta/YWHAB	Human	14-3-3 beta/YWHAB Protein, Recombinant
14-3-3 eta/YWHAH	Human	14-3-3 eta/YWHAH Protein, Recombinant, GST Tag
14-3-3 tau/14-3-3 theta/YWHAQ	Human	YWHAQ/14-3-3 tau/14-3-3 theta Protein, Recombinant, GST Tag
14-3-3 sigma/Stratifin/YWHAS	Human	14-3-3 sigma/Stratifin/YWHAS Protein, Recombinant, With GST Tag
14-3-3 sigma/Stratifin/YWHAS	Human	14-3-3 sigma/Stratifin/YWHAS Protein, Recombinant
14-3-3 sigma/Stratifin/YWHAS	Mouse	14-3-3 sigma/Stratifin/YWHAS Protein, Recombinant

cDNA Clone Products

Molecule	Species	Description //For Detailed Info. and Price------CLICK!
14-3-3 beta/YWHAB	Human	Homo sapiens 14-3-3 beta/YWHAB cDNA Clone(NM_003404.3)
14-3-3 gamma/YWHAG	Human	Homo sapiens 14-3-3 gamma/YWHAG cDNA Clone(NM_012479.3)
14-3-3 eta/YWHAH	Human	Human 14-3-3 eta/YWHAH cDNA Clone / ORF Clone
14-3-3 eta/YWHAH	Mouse	Mouse 14-3-3 eta/YWHAH cDNA Clone / ORF Clone
14-3-3 tau/14-3-3 theta/YWHAQ	Human	Human 14-3-3 tau/14-3-3 theta/YWHAQ cDNA Clone / ORF Clone
14-3-3 sigma/Stratifin/YWHAS	Human	Homo sapiens 14-3-3 sigma/Stratifin/YWHAS cDNA Clone(NM_006142.3)
14-3-3 sigma/Stratifin/YWHAS	Mouse	Mus musculus 14-3-3 sigma/Stratifin/YWHAS cDNA Clone