YWHAB Protein Price Inquiry ( Available Sizes )
YWHAB Protein Product Information
||A DNA sequence encoding the mature form of Cynomolgus (Macaca fascicularis) YWHAB (Q4R572-2 ) (Met 2-Asn 244 ) was expressed and purified, with an initial Met.
YWHAB Protein QC Testing
||> 90% as determined by SDS-PAGE.
||Please contact us for more information.
||Samples are stable for up to twelve months from date of receipt at -70℃
|Predicted N terminal:
||The recombinant Cynomolgus YWHAB consists of 246 amino acids and has a calculated molecular mass of 27.8 KDa. It migrates as an approximately 30 KDa band in SDS-PAGE under reducing conditions.
||Lyophilized from sterile PBS, 10%glycerol, 0.5mM DTT , pH7.5
- Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
- Please contact us for any concerns or special requirements.
YWHAB Protein Usage Guide
||Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
||A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
YWHAB Protein Related Products & Topics
YWHAB Protein Description
Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide (YWHAB), also known as 14-3-3 protein beta / alpha and protein kinase C inhibitor protein 1(KCIP1), is a member of the 14-3-3 proteins which are a family of conserved regulatory molecules expressed in all eukaryotic cells. The name 14-3-3 refers to the particular elution and migration pattern of these proteins on DEAE-cellulose chromatography and starch-gel electrophoresis. The 14-3-3 proteins eluted in the 14th fraction of bovine brain homogenate and were found on positions 3.3 of subsequent electrophoresis. There are seven genes that encode 14-3-3s in most mammals. 14-3-3 proteins have been identified as adapter proteins implicated in the regulation of a large spectrum of both general and specialized signaling pathway. More than 100 signaling proteins have been reported as 14-3-3 ligands including kinases, phosphatases, and transmembrane receptors, and the binding generally results in the modulation of the activity of the binding partner. YWHAB has been repoted to interact with SSH1,TORC2/CRTC2, ABL1, ROR2, GAB2, and thus is invloved in the related processes, such as apoptosis. Inaddition, YWHAB may serve as a negative regulator of osteogenesis.
- Mhawech P. et al., 2005, Cell Res. 15: 228-36.
- Screaton R A. et al., 2004, Cell.119: 61-74.
- Brummer T. et al., 2008, EMBO J. 27: 2305-16.
- Yang X. et al., 2006, Proc Natl Acad Sci.103: 17237-42.
- Liu Y. et al., 2007, Mol Endocrinol. 21: 3050-61.
YWHAB / KCIP-1 / 14-3-3 beta related areas, pathways, and other information