14-3-3 beta / YWHAB Protein

Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide

14-3-3 beta / YWHAB Products

14-3-3 beta / YWHAB Protein, Recombinant

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
14-3-3 beta/YWHAB	Human	14-3-3 beta / YWHAB Protein, Recombinant, with GST Tag	10843-H09E
14-3-3 beta/YWHAB	Human	14-3-3 beta / YWHAB Protein, Recombinant	10843-HNCE
14-3-3 beta/YWHAB	Cynomolgus	14-3-3 beta / YWHAB Protein, Recombinant	90022-CNCE

14-3-3 beta / YWHAB Antibody

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
Cynomolgus 14-3-3 beta / YWHAB	WB, ELISA	14-3-3 beta / YWHAB Antibody	90022-MM05

14-3-3 beta / YWHAB cDNA Clone

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
14-3-3 beta/YWHAB	Human	Homo sapiens 14-3-3 beta/YWHAB cDNA Clone(NM_003404.3)	HG10843-M
14-3-3 beta/YWHAB	Mouse	Mouse 14-3-3 beta/YWHAB cDNA Clone / ORF Clone	MG50861-G
14-3-3 beta/YWHAB	Cynomolgus	Cynomolgus monkey 14-3-3 beta/YWHAB cDNA Clone / ORF Clone	CG90022-G

14-3-3 beta / YWHAB Related Areas

Cancer>>Apoptosis>>Death Receptor & Ligand>>14-3-3 beta/YWHAB

Signal Transduction>>Adaptor Protein>>14-3-3 beta/YWHAB

14-3-3 beta / YWHAB Alternative Names

14-3-3 protein beta, YWHAB, GW128, HS1, KCIP-1 [Homo sapiens]

14-3-3 protein beta, Ywhab, RP23-321M14.1, 1300003C17Rik [Mus musculus]

14-3-3 beta / YWHAB Background

14-3-3 beta / YWHAB is a member of the 14-3-3 proteins family. 14-3-3 proteins are a group of highly conserved proteins that are involved in many vital cellular processes such as metabolism, protein trafficking, signal transduction, apoptosis and cell cycle regulation. 14-3-3 proteins are mainly localized in the synapses and neuronal cytoplasm, and seven isoforms have been identified in mammals. This family of proteins was initially identified as adaptor proteins which bind to phosphoserine-containing motifs. Binding motifs and potential functions of 14-3-3 proteins are now recognized to have a wide range of functional relevance. 14-3-3 beta / YWHAB is found in both plants and mammals, and this protein is 100% identical to the mouse ortholog. 14-3-3 beta / YWHAB interacts with CDC25 phosphatases, RAF1 and IRS1 proteins, suggesting its role in diverse biochemical activities related to signal transduction, such as cell division and regulation of insulin sensitivity. 14-3-3 beta / YWHAB has also been implicated in the pathogenesis of small cell lung cancer. 14-3-3 beta / YWHAB binding negatively regulates RSK1 activity to maintain signal specificity and that association/dissociation of the 14-3-3beta-RSK1 complex is likely to be important for mitogen-mediated RSK1 activation.

14-3-3 beta / YWHAB Related Studies

1. Tommerup N, et al. (1996) Assignment of the human genes encoding 14,3-3 Eta (YWHAH) to 22q12, 14-3-3 zeta (YWHAZ) to 2p25.1-p25.2, and 14-3-3 beta (YWHAB) to 20q13.1 by in situ hybridization. Genomics. 33(1): 149-50.
2. Jin YH, et al. (2008) Sirt2 interacts with 14-3-3 beta/gamma and down-regulates the activity of p53. Biochem Biophys Res Commun. 368(3): 690-5.
3. Sekimoto T, et al. (2004) 14-3-3 suppresses the nuclear localization of threonine 157-phosphorylated p27(Kip1). EMBO J. 23(9): 1934-42.

14-3-3 beta / YWHAB Related Products

Protein Products

Molecule	Species	Description //For Detailed Info. and Price------CLICK!
14-3-3 epsilon/YWHAE	Human	14-3-3 epsilon/YWHAE Protein, Recombinant, With GST Tag
14-3-3 epsilon/YWHAE	Human	14-3-3 epsilon/YWHAE Protein, Recombinant
14-3-3 epsilon/YWHAE	Mouse	14-3-3 epsilon/YWHAE Protein, Recombinant, with GST Tag
14-3-3 eta/YWHAH	Human	14-3-3 eta/YWHAH Protein, Recombinant, GST Tag
14-3-3 tau/14-3-3 theta/YWHAQ	Human	YWHAQ/14-3-3 tau/14-3-3 theta Protein, Recombinant, GST Tag
14-3-3 sigma/Stratifin/YWHAS	Human	14-3-3 sigma/Stratifin/YWHAS Protein, Recombinant, With GST Tag
14-3-3 sigma/Stratifin/YWHAS	Human	14-3-3 sigma/Stratifin/YWHAS Protein, Recombinant
14-3-3 sigma/Stratifin/YWHAS	Mouse	14-3-3 sigma/Stratifin/YWHAS Protein, Recombinant

cDNA Clone Products

Molecule	Species	Description //For Detailed Info. and Price------CLICK!
14-3-3 epsilon/YWHAE	Human	Homo sapiens 14-3-3 epsilon/YWHAE cDNA Clone(NM_006761.4)
14-3-3 epsilon/YWHAE	Mouse	Mouse 14-3-3 epsilon/YWHAE cDNA Clone / ORF Clone
14-3-3 epsilon/YWHAE	Rat	Rat 14-3-3 epsilon/YWHAE cDNA Clone / ORF Clone
14-3-3 gamma/YWHAG	Human	Homo sapiens 14-3-3 gamma/YWHAG cDNA Clone(NM_012479.3)
14-3-3 eta/YWHAH	Human	Human 14-3-3 eta/YWHAH cDNA Clone / ORF Clone
14-3-3 eta/YWHAH	Mouse	Mouse 14-3-3 eta/YWHAH cDNA Clone / ORF Clone
14-3-3 tau/14-3-3 theta/YWHAQ	Human	Human 14-3-3 tau/14-3-3 theta/YWHAQ cDNA Clone / ORF Clone
14-3-3 sigma/Stratifin/YWHAS	Human	Homo sapiens 14-3-3 sigma/Stratifin/YWHAS cDNA Clone(NM_006142.3)
14-3-3 sigma/Stratifin/YWHAS	Mouse	Mus musculus 14-3-3 sigma/Stratifin/YWHAS cDNA Clone