Anti-14-3-3 beta Antibody

14-3-3 beta / YWHAB is a member of the 14-3-3 proteins family. 14-3-3 proteins are a group of highly conserved proteins that are involved in many vital cellular processes such as metabolism, protein trafficking, signal transduction, apoptosis and cell cycle regulation. 14-3-3 proteins are mainly localized in the synapses and neuronal cytoplasm, and seven isoforms have been identified in mammals. This family of proteins was initially identified as adaptor proteins which bind to phosphoserine-containing motifs. Binding motifs and potential functions of 14-3-3 proteins are now recognized to have a wide range of functional relevance. 14-3-3 beta / YWHAB is found in both plants and mammals, and this protein is 1% identical to the mouse ortholog. 14-3-3 beta / YWHAB interacts with CDC25 phosphatases, RAF1 and IRS1 proteins, suggesting its role in diverse biochemical activities related to signal transduction, such as cell division and regulation of insulin sensitivity. 14-3-3 beta / YWHAB has also been implicated in the pathogenesis of small cell lung cancer. 14-3-3 beta / YWHAB binding negatively regulates RSK1 activity to maintain signal specificity and that association/dissociation of the 14-3-3beta-RSK1 complex is likely to be important for mitogen-mediated RSK1 activation.

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta

• Cancer>>Signal Transduction>>Adaptor Proteins
• Cancer>>Signal Transduction>>Akt Pathway>>Adaptor Proteins in the Akt Pathway
• Cancer>>Signal Transduction>>Signaling Pathway>>Representative pathway>>Apoptosis Signaling pathway>>Apoptosis Adaptor Proteins
• Cell Biology>>Apoptosis>>Apoptosis Receptors>>Associated Proteins
• Cancer>>Signal Transduction>>Signaling Pathway>>Representative pathway>>Apoptosis Signaling pathway>>Bcl-2 Proteins and Regulators
• Neuroscience>>Neurotransmission>>Intracellular Signaling>>Adapters>>Cytoplasmic
• Neuroscience>>Neurology process>>Neural Signal Transduction
• Neuroscience>>Neurology process>>Growth and Development>>Axon Guidance>>Other Axon Guidance Proteins
• Cancer>>Cell Cycle>>Cell division>>Other cell division related protein
• Cancer>>Signal Transduction>>phospho-Serine/phospho-Threonine Binding Proteins

• Tommerup N, et al. (1996) Assignment of the human genes encoding 14,3-3 Eta (YWHAH) to 22q12, 14-3-3 zeta (YWHAZ) to 2p25.1-p25.2, and 14-3-3 beta (YWHAB) to 20q13.1 by in situ hybridization. Genomics. 33(1): 149-50.
• Jin YH, et al. (2008) Sirt2 interacts with 14-3-3 beta/gamma and down-regulates the activity of p53. Biochem Biophys Res Commun. 368(3): 690-5.
• Sekimoto T, et al. (2004) 14-3-3 suppresses the nuclear localization of threonine 157-phosphorylated p27(Kip1). EMBO J. 23(9): 1934-42.