|Catalog||Size (Price)||Quantity||In Stock||Operation||Other Information|
14-3-3 protein beta/alpha ( YWHAB / KCIP-1 ) Protein Datasheet
YWHAB / KCIP-1 Protein Price Information
- ≥1mg Bulk: Inquiring Price
YWHAB / KCIP-1 Protein Product Information
GW128 , HS1 , KCIP-1 , YWHAB
A DNA sequence encoding the human YWHAB ( NP_003395.1 ) ( Met 1- Asn 246 ) was expressed, with two additional amino acids (Gly & Pro) at the N-terminus
YWHAB / KCIP-1 Protein QC Testing
|Purity:||> 93 % as determined by SDS-PAGE||SDS-PAGE:
|Endotoxin:||Please contact us for more information.|
|Stability:||Samples are stable for up to twelve months from date of receipt at -70℃|
|Predicted N terminal:||Met|
The recombinant human YWHAB consists of 248 amino acids and has a predicted molecular mass of 28 kDa as estimated in SDS-PAGE under reducing conditions
Lyophilized from sterile 20mM Tris, 150mM NaCl, 0.1mM DTT, 10% glycerol, pH 7.5
YWHAB / KCIP-1 Protein Usage Guide
|Storage:||Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.|
|Reconstitution:||A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.|
YWHAB / KCIP-1 Protein Related Products & Topics
|14-3-3 beta/YWHAB||Human||14-3-3 beta / YWHAB Protein, Recombinant, with GST Tag||10843-H09E|
YWHAB / KCIP-1 Protein Description
Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide (YWHAB), also known as 14-3-3 protein beta / alpha and protein kinase C inhibitor protein 1(KCIP1), is a member of the 14-3-3 proteins which are a family of conserved regulatory molecules expressed in all eukaryotic cells. The name 14-3-3 refers to the particular elution and migration pattern of these proteins on DEAE-cellulose chromatography and starch-gel electrophoresis. The 14-3-3 proteins eluted in the 14th fraction of bovine brain homogenate and were found on positions 3.3 of subsequent electrophoresis. There are seven genes that encode 14-3-3s in most mammals. 14-3-3 proteins have been identified as adapter proteins implicated in the regulation of a large spectrum of both general and specialized signaling pathway. More than 100 signaling proteins have been reported as 14-3-3 ligands including kinases, phosphatases, and transmembrane receptors, and the binding generally results in the modulation of the activity of the binding partner. YWHAB has been repoted to interact with SSH1,TORC2/CRTC2, ABL1, ROR2, GAB2, and thus is invloved in the related processes, such as apoptosis. Inaddition, YWHAB may serve as a negative regulator of osteogenesis.
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- Screaton, R.A. et al., 2004, Cell.119:61-74
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- Yang, X. et al., 2006, Proc. Natl. Acad. Sci. U.S.A. 103: 17237-17242.
- Liu, Y. et al., 2007, Mol. Endocrinol. 21: 3050-3061.